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Proteintech
CNOT6 Polyclonal Antibody
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Product Details
17935-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MCIMTISSEG ELELVGLMRL RKQLFLRSAL CNHRSRELYG SGRGGALTHV VFVNGGCHLF IDAGTRVHLL DAKGLSFTQN VFICICYCLQ YI
Target Information
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; Cytoplasmic deadenylase
Gene Aliases: CCR4; Ccr4a; Cnot6; Kiaa1194
UniProt ID: (Mouse) Q8K3P5
Entrez Gene ID: (Human) 57472, (Mouse) 104625
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of translation
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
gene silencing by RNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear-transcribed mRNA catabolic process, no-go decay
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
nuclear-transcribed mRNA poly(A) tail shortening
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
gene silencing by miRNA
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