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CNPY2/MSAP Polyclonal Antibody

CNPY2/MSAP Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

CNPY2/MSAP Antibody (14635-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14635-1-AP (CNPY2,MSAP antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CNPY2/MSAP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CNPY2/MSAP Antibody in Western Blot (WB)

CNPY2/MSAP Antibody in Flow Cytometry (Flow)

CNPY2/MSAP Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14635-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CNPY2,MSAP Fusion Protein Ag6214 (1-182 aa encoded by BC065015)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to CNPY2.

Immunogen sequence: MKGWGWLAL LLGALLGTAW ARRSQDLHCG ACRALVDELE WEIAQVDPKK TIQMGSFRIN PDGSQSVVEV PYARSEAHLT ELLEEICDRM KEYGEQIDPS THRKNYVRVV GRNGESSELD LQGIRIDSDI SGTLKFACES IVEEYEDELI EFFSREADNV KDKLCSKRTD LCDHALHISH DEL (1-182 aa encoded by BC065015)

Target Information

CNPY2 is positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.

Apoptosis : an international journal on programmed cell death

Guo CL,Liu HM,Li B,Lu ZY

Sat Apr 01 00:00:00 UTC 2023

Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.

Apoptosis : an international journal on programmed cell death

Guo CL,Liu HM,Li B,Lu ZY

Sat Apr 01 00:00:00 UTC 2023

MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling.

World journal of gastrointestinal oncology

Gu XJ,Li YJ,Wang F,Ye T

Tue Nov 15 00:00:00 UTC 2022

Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.

Biochemical and biophysical research communications

Li J,Huang L,Xiong W,Qian Y,Song M

Sat May 07 00:00:00 UTC 2022

Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway.

Biochemical and biophysical research communications

Li J,Huang L,Xiong W,Qian Y,Song M

Sat May 07 00:00:00 UTC 2022

Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.

Frontiers in pharmacology

Zhao L,Li H,Gao Q,Xu J,Zhu Y,Zhai M,Zhang P,Shen N,Di Y,Wang J,Chen T,Huang M,Sun J,Liu C

Tue May 18 00:00:00 UTC 2021

Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.

Frontiers in pharmacology

Zhao L,Li H,Gao Q,Xu J,Zhu Y,Zhai M,Zhang P,Shen N,Di Y,Wang J,Chen T,Huang M,Sun J,Liu C

Tue May 18 00:00:00 UTC 2021

Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.

Frontiers in pharmacology

Zhao L,Li H,Gao Q,Xu J,Zhu Y,Zhai M,Zhang P,Shen N,Di Y,Wang J,Chen T,Huang M,Sun J,Liu C

Tue May 18 00:00:00 UTC 2021

Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.

Cancers

Kakehashi A,Suzuki S,Shiota M,Raymo N,Gi M,Tachibana T,Stefanov V,Wanibuchi H

Mon Jul 19 00:00:00 UTC 2021

Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?

Neural regeneration research

Liu AM,Chen BL,Yu LT,Liu T,Shi LL,Yu PP,Qu YB,So KF,Zhou LB

Tue Dec 01 00:00:00 UTC 2020

Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.

Frontiers in pharmacology

Liu C,Liu Y,He J,Mu R,Di Y,Shen N,Liu X,Gao X,Wang J,Chen T,Fang T,Li H,Tian F

Thu Oct 01 00:00:00 UTC 2020

Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.

Journal of cellular and molecular medicine

Zhao L,Zhai M,Yang X,Guo H,Cao Y,Wang D,Li P,Liu C

Sun Dec 01 00:00:00 UTC 2019

Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway.

International journal of molecular medicine

Cui Y,Wang Y,Liu G

Wed May 01 00:00:00 UTC 2019

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.

Nature structural & molecular biology

Hong F,Liu B,Wu BX,Morreall J,Roth B,Davies C,Sun S,Diehl JA,Li Z

Sun Oct 01 00:00:00 UTC 2017

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.

Nature structural & molecular biology

Hong F,Liu B,Wu BX,Morreall J,Roth B,Davies C,Sun S,Diehl JA,Li Z

Sun Oct 01 00:00:00 UTC 2017

CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.

Nature structural & molecular biology

Hong F,Liu B,Wu BX,Morreall J,Roth B,Davies C,Sun S,Diehl JA,Li Z

Sun Oct 01 00:00:00 UTC 2017

Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.

The Journal of biological chemistry

Do HT,Bruelle C,Tselykh T,Jalonen P,Korhonen L,Lindholm D

Fri Oct 11 00:00:00 UTC 2013

Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.

The Journal of biological chemistry

Do HT,Bruelle C,Tselykh T,Jalonen P,Korhonen L,Lindholm D

Fri Oct 11 00:00:00 UTC 2013

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).

The Journal of biological chemistry

Do HT,Tselykh TV,Mäkelä J,Ho TH,Olkkonen VM,Bornhauser BC,Korhonen L,Zelcer N,Lindholm D

Fri Apr 13 00:00:00 UTC 2012

The Journal of biological chemistry

Do HT,Tselykh TV,Mäkelä J,Ho TH,Olkkonen VM,Bornhauser BC,Korhonen L,Zelcer N,Lindholm D

Fri Apr 13 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: canopy 2 homolog; MIR-interacting saposin-like protein; Protein canopy homolog 2; Putative secreted protein ZSIG9; Transmembrane protein 4

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Gene Aliases: 5330432A10Rik; AW229003; CNPY2; D10Bwg1546e; HP10390; MSAP; TMEM4; UNQ1943/PRO4426; ZSIG9

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UniProt ID: (Human) Q9Y2B0, (Mouse) Q9QXT0

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Entrez Gene ID: (Human) 10330, (Mouse) 56530, (Rat) 685814

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Function(s)

protein binding molecular_function

Process(es)

negative regulation of gene expression regulation of low-density lipoprotein particle clearance positive regulation of low-density lipoprotein particle receptor biosynthetic process enzyme linked receptor protein signaling pathway tissue development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CNPY2/MSAP Polyclonal Antibody

CNPY2/MSAP Antibody (14635-1-AP) in ICC/IF

Product Details

14635-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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