Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CNR2 Recombinant Rabbit Monoclonal Antibody (13H43L20)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 4
CNR2 Antibody (703485) in ICC/IF
HEK-293 cells transiently transfected with CNR2 were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti-CNR2 Recombinant Rabbit Monoclonal Antibody (Product # 703485, 1:500 dilution). Cells were then incubated with Alexa488-conjugated secondary antibody for 2 h at room temperatur... View More
Product Details
703485
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
13H43L20
Immunogen
Peptides corresponding to human CNR2 [1) aa341-aa360, 2) aa5-aa25, 3) aa2-25]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2895879
Product Specific Information
This antibody is predicted to react with Rat, Bovine.
Target Information
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2
Gene Aliases: CB-2; CB2; CB2-R; CB2A; CB2B; CNR2; CX5
UniProt ID: (Human) P34972, (Mouse) P47936
Entrez Gene ID: (Human) 1269, (Mouse) 12802
response to amphetamine
inflammatory response
immune response
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
cannabinoid signaling pathway
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support