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Invitrogen
CNTNAP1 Recombinant Rabbit Monoclonal Antibody (23GB5605)
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FIGURE: 1 / 2
CNTNAP1 Antibody (MA5-53910) in WB
Western Blot analysis of CNTNAP1. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CNTNAP1 recombinant monoclonal antibody (Product # MA5-53910) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Product Details
MA5-53910
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5605
Immunogen
A synthesized peptide derived from human Caspr (700-770AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3248381
Target Information
CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Caspr; caspr1; contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP1; neurexin 4 (contactin associated protein); Neurexin IV; Neurexin-4; p190; Paranodin
Gene Aliases: AI841080; CASPR; CNTNAP; CNTNAP1; NCP1; NRXN4; P190; shm
UniProt ID: (Human) P78357, (Mouse) O54991
Entrez Gene ID: (Human) 8506, (Mouse) 53321
protein localization to paranode region of axon
cytoskeleton organization
cell adhesion
neuronal action potential propagation
paranodal junction assembly
neuron projection development
neuron projection morphogenesis
neuromuscular process controlling posture
neuromuscular process controlling balance
signal transduction
positive regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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