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Invitrogen
COCH Polyclonal Antibody
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COCH Antibody (PA5-48475) in IHC (P)
Immunohistochemistry analysis of COCH in formalin fixed and paraffin embedded human skeletal muscle. Samples were incubated with COCH polyclonal antibody (Product # PA5-48475) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-48475
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 399-428 amino acids from the Central region of human COCH.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633932
Product Specific Information
Predicted to react with bovine based on sequence homology.
Target Information
Cochlin is a secreted protein encoded by the coagulation factor C homology (COCH) gene, a cochlear gene. It constitutes 70% of the inner ear proteins and is classified into three glycosylated isoforms: p63s, p44s and p40. Cochlin contains an N-terminal LCCL domain and two von Willebrand factor A-like domains. Mutations in the COCH gene cause DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder, as a result of either an amino acid deletion in the LCCL domain or missense substitutions. Microfibrillar deposits accumulate in the inner ear of individuals with DFNA9 and these deposits may contain the Cochlin protein. Cochlin is a target antigen for autoimmune sensorineural hearing loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coagulation factor C homolog, cochlin (Limulus polyphemus); COCH-5B2; Cochlin; PRO294; UNQ257
Gene Aliases: COCH; COCH-5B2; COCH5B2; DFNA9; UNQ257/PRO294
UniProt ID: (Human) O43405
Entrez Gene ID: (Human) 1690
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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