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Invitrogen
COL11A1 Polyclonal Antibody
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FIGURE: 1 / 3
COL11A1 Antibody (PA5-68410) in IHC (P)
Immunohistochemical analysis of COL11A1 in paraffin-embedded Human thyroid cancer tissue using (left) COL11A1 Polyclonal Antibody (Product # PA5-68410). at a 1:25 dilution and (right) is treated with fusion protein. (Original magnification: x200).
Product Details
PA5-68410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic protein corresponding to internal residues of human COL11A1.
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2688459
Target Information
Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI). a 3(XI) is a post-translational modification of a 1(II). a 1(V) can also be found instead of a 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COBA1; Collagen alpha 1; Collagen alpha-1(XI) chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; STL3; XI chain precursor
Gene Aliases: CO11A1; COL11A1; COLL6; STL2
UniProt ID: (Human) P12107
Entrez Gene ID: (Human) 1301
cartilage condensation
ossification
chondrocyte development
proteoglycan metabolic process
visual perception
sensory perception of sound
extracellular matrix organization
collagen fibril organization
collagen catabolic process
endodermal cell differentiation
tendon development
inner ear morphogenesis
embryonic skeletal system morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
ventricular cardiac muscle tissue morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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