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Abnova
COMT Monoclonal Antibody (1G4-1A1)
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Product Details
H00001312-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1G4-1A1
Immunogen
COMT (AAH00419.2, 1 a.a. approximately 182 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MNVGDKKGKI VDAVIQEHQP SVLLELGAYC GYSAVRMARL LSPGARLITI EINPDCAAIT QRMVDFAGMK DKVTLVVGAS QDIIPQLKKK YDVDTLDMVF LDHWKDRYLP DTLLLEECGL LRKGTVLLAD NVICPGAPDF LAHVRGSSCF ECTHYQSFLE YREVVDGLEK AIYKGPGSEA GP
Target Information
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Catechol O-methyltransferase; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
Gene Aliases: COMT; HEL-S-98n
UniProt ID: (Human) P21964
Entrez Gene ID: (Human) 1312
female pregnancy
learning
short-term memory
estrogen metabolic process
response to organic cyclic compound
cellular response to phosphate starvation
methylation
response to lipopolysaccharide
developmental process
negative regulation of renal sodium excretion
neurotransmitter catabolic process
dopamine catabolic process
response to drug
negative regulation of dopamine metabolic process
response to pain
multicellular organismal reproductive process
negative regulation of smooth muscle cell proliferation
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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