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Immunogen sequence: GLKNFERALY FYEQAITTPA MAVSHIMLES YKKYILVSLI LLGKVQQLPK YTSQIVGRFI KPLSNAYHEL AQVYSTNNPS ELRNLVNKHS ETFTRDNNMG LVKQCLSSLY KKNIQRLTKT FLTLSLQDMA SRVQLSGPQE AEKYVLHMIE DGEIFASINQ KDGMVSFHDN PEKYNNPAML HNIDQEMLKC IELDERLKAM DQEITVNPQF VQKSMGSQED DSGNKPSSYS; Positive Samples: SW480, HeLa, 293T, Mouse heart, Rat heart, Rat brain; Cellular Location: Cytoplasm, Nucleus
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COP9 (constitutive photomorphogenic) homolog, subunit 3; COP9 (constitutive photomorphogenic), subunit 3; COP9 complex S3; COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 signalosome complex subunit 3; COPS 3; JAB1-containing signalosome subunit 3; SGN3; signalosome subunit 3
Gene Aliases: COPS3; CSN3; SGN3
UniProt ID: (Human) Q9UNS2, (Mouse) O88543, (Rat) Q68FW9
Entrez Gene ID: (Human) 8533, (Mouse) 26572, (Rat) 287367
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