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Immunogen sequence: MAAAVRQDL AQLMNSSGSH KDLAGKYRQI LEKAIQLSGA EQLEALKAFV EAMVNENVSL VISRQLLTDF CTHLPNLPDS TAKEIYHFTL EKIQPRVISF EEQVASIRQH LASIYEKEED WRNAAQVLVG IPLETGQKQY NVDYKLETYL KIARLYLEDD DPVQAEAYIN RASLLQNEST NEQLQIHYKV CYARVLDYRR KFIEAAQRYN ELSYKTIVHE SERLEALKHA LHCTILASAG QQRSRMLATL F (1-250 aa encoded by BC004302)
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COP9 (constitutive photomorphogenic) homolog, subunit 4; COP9 (constitutive photomorphogenic), subunit 4; COP9 complex S4; COP9 constitutive photomorphogenic homolog subunit 4; COP9 constitutive photomorphogenic-like protein subunit 4; COP9 signalosome complex subunit 4; JAB1-containing signalosome subunit 4; SGN4; signalosome subunit 4; testis tissue sperm-binding protein Li 42a
Gene Aliases: AW208976; COPS4; CSN4; D5Ertd774e
UniProt ID: (Human) Q9BT78, (Mouse) O88544, (Rat) Q68FS2
Entrez Gene ID: (Human) 51138, (Mouse) 26891, (Rat) 360915
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