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Proteintech
COPS7A Polyclonal Antibody
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Product Details
16628-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
COPS7A Fusion Protein Ag9958 (1-275 aa encoded by BC011789)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSAEVKVTG QNQEQFLLLA KSAKGAALAT LIHQVLEAPG VYVFGELLDM PNVRELAESD FASTFRLLTV FAYGTYADYL AEARNLPPLT EAQKNKLRHL SVVTLAAKVK CIPYAVLLEA LALRNVRQLE DLVIEAVYAD VLRGSLDQRN QRLEVDYSIG RDIQRQDLSA IARTLQEWCV GCEVVLSGIE EQVSRANQHK EQQLGLKQQI ESEVANLKKT IKVTTAAAAA ATSQDPEQHL TELREPAPGT NQRQPSKKAS KGKGLRGSAK IWSKSN (1-275 aa encoded by B C011789)
Target Information
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COP9 (constitutive photomorphogenic) homolog, subunit 7a; COP9 (constitutive photomorphogenic), subunit 7a; COP9 complex S7a; COP9 complex subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A; COP9 signalosome complex subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; SGN7a; signalosome subunit 7a
Gene Aliases: COPS7A; CSN7; CSN7A; D6Ertd35e; DERP10; SGN7a
UniProt ID: (Human) Q9UBW8, (Mouse) Q9CZ04
Entrez Gene ID: (Human) 50813, (Rat) 312710, (Mouse) 26894
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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