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Proteintech
COPS8/COP9 Polyclonal Antibody
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Product Details
10089-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
COPS8/COP9 Fusion Protein Ag0143 (14-194 aa encoded by BC003090)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KKLLDQCEN QELEAPGGIA TPPVYGQLLA LYLLHNDMNN ARYLWKRIPP AIKSANSELG GIWSVGQRIW QRDFPGIYTT INAHQWSETV QPIMEALRDA TRRRAFALVS QAYTSIIADD FAAFVGLPVE EAVKGILEQG WQADSTTRMV LPRKPVAGAL DVSFNKFIPL SEPAPVPPIP NE (14-194 aa encoded by BC003090)
Target Information
COPS8 is a COP9 signalosome (CSN), which is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; COP9 signalosome subunit 8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8
Gene Aliases: 9430009J09Rik; AA408242; COP9; COPS8; CSN8; SGN8
UniProt ID: (Human) Q99627, (Mouse) Q8VBV7
Entrez Gene ID: (Human) 10920, (Mouse) 108679
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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