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Invitrogen
COQ10B Polyclonal Antibody
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FIGURE: 1 / 1
COQ10B Antibody (PA5-90284) in WB
Western blot analysis of COQ10B in extracts of various cell lines. Samples were incubated with COQ10B Polyclonal antibody (Product # PA5-90284) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-90284
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 38-150 of human COQ10B (NP_0794231)
Conjugate
Form
Liquid
Concentration
1.11 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806000
Product Specific Information
Immunogen sequence: ASCGILMSRT LPLHTSILPK EICARTFFKI TAPLINKRKE YSERRILGYS MQEMYDVVSG VEDYKHFVPW CKKSDVISKR SGYCKTRLEI GFPPVLERYT SVVTLVKPHL VKA; Positive Samples: Mouse heart, Mouse testis, Mouse thymus, Rat heart, Rat testis; Cellular Location: Matrix side, Mitochondrion inner membrane, Peripheral membrane protein
Target Information
COQ10B, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10B. COQ10B is a mitochondrial protein that belongs to the COQ10 family. COQ10B is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10B levels decrease in patients with advanced chronic heart failure (CHF) while COQ10B levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10B is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10B levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10B levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
Gene Aliases: 1500041J02Rik; 1700030I21Rik; 9530077A17Rik; AV002237; AW742641; Coq10b; RGD1359509
UniProt ID: (Rat) Q5I0I9, (Mouse) Q3THF9
Entrez Gene ID: (Rat) 301416, (Mouse) 67876
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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