Proteintech

COQ7 Polyclonal Antibody

COQ7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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COQ7 Antibody (15083-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer using 15083-1-AP (COQ7 antibody) at dilution of 1:100 (under 40x lens).

COQ7 Antibody in Immunoprecipitation (IP)

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Product Details

15083-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 20 publications 20 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COQ7 Fusion Protein Ag7161 (1-217 aa encoded by BC003185)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSCAGAAAA PRLWRLRPGA RRSLSAYGRR TSVRFRSSGM TLDNISRAAV DRIIRVDHAG EYGANRIYAG QMAVLGRTSV GPVIQKMWDQ EKDHLKKFNE LMVTFRVRPT VLMPLWNVLG FALGAGTALL GKEGAMACTV AVEESIAHHY NNQIRTLMEE DPEKYEELLQ LIKKFRDEEL EHHDIGLDHD AELAPAYAVL KSIIQAGCRV AIYLSERL (1-217 aa encoded by BC003185)

Target Information

The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy.

Brain : a journal of neurology

Jacquier A,Theuriet J,Fontaine F,Mosbach V,Lacoste N,Ribault S,Risson V,Carras J,Coudert L,Simonet T,Latour P,Stojkovic T,Piard J,Cosson A,Lesca G,Bouhour F,Allouche S,Puccio H,Pegat A,Schaeffer L

Tue Aug 01 00:00:00 UTC 2023

Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy.

Neurology. Genetics

Smith IC,Pileggi CA,Wang Y,Kernohan K,Hartley T,McMillan HJ,Sampaio ML,Melkus G,Woulfe J,Parmar G,Bourque PR,Breiner A,Zwicker J,Pringle CE,Jarinova O,Lochmüller H,Dyment DA,Brais B,Boycott KM,Hekimi S,Harper ME,Warman-Chardon J

Wed Feb 01 00:00:00 UTC 2023

The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains functional by metalation with cobalt.

microPublication biology

Wang Y,Hekimi S

Sat Oct 01 00:00:00 UTC 2022

A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options.

Molecular genetics and metabolism reports

Wang Y,Gumus E,Hekimi S

Wed Jun 01 00:00:00 UTC 2022

Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes.

Journal of medical genetics

Laugwitz L,Seibt A,Herebian D,Peralta S,Kienzle I,Buchert R,Falb R,Gauck D,Müller A,Grimmel M,Beck-Woedel S,Kern J,Daliri K,Katibeh P,Danhauser K,Leiz S,Alesi V,Baertling F,Vasco G,Steinfeld R,Wagner M,Caglayan AO,Gumus H,Burmeister M,Mayatepek E,Martinelli D,Tamhankar PM,Tamhankar V,Joset P,Steindl K,Rauch A,Bonnen PE,Froukh T,Groeschel S,Krägeloh-Mann I,Haack TB,Distelmaier F

Thu Sep 01 00:00:00 UTC 2022

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation.

Frontiers in immunology

Kusakari K,Machida T,Ishida Y,Omori T,Suzuki T,Sekimata M,Wada I,Fujita T,Sekine H

Thu Sep 08 00:00:00 UTC 2022

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.

Redox biology

González-García P,Díaz-Casado ME,Hidalgo-Gutiérrez A,Jiménez-Sánchez L,Bakkali M,Barriocanal-Casado E,Escames G,Chiozzi RZ,Völlmy F,Zaal EA,Berkers CR,Heck AJR,López LC

Thu Sep 01 00:00:00 UTC 2022

Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.

Acta pharmacologica Sinica

Yan PJ,Ren ZX,Shi ZF,Wan CL,Han CJ,Zhu LS,Li NN,Waddington JL,Zhen XC

Fri Jul 01 00:00:00 UTC 2022

Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation.

Artificial organs

Pan HZ,Zhang LJ,Liu YW,Li YN,Su ZH,Meng J,Zhang H

Thu Oct 01 00:00:00 UTC 2020

Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.

Antioxidants (Basel, Switzerland)

Meza-Torres C,Hernández-Camacho JD,Cortés-Rodríguez AB,Fang L,Bui Thanh T,Rodríguez-Bies E,Navas P,López-Lluch G

Fri May 15 00:00:00 UTC 2020

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Nature communications

Zhang Z,Zong C,Jiang M,Hu H,Cheng X,Ni J,Yi X,Jiang B,Tian F,Chang MW,Su W,Zhu L,Li J,Xiang X,Miao C,Gorospe M,de Cabo R,Dou Y,Ju Z,Yang J,Jiang C,Yang Z,Wang W

Tue Jun 16 00:00:00 UTC 2020

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Scientific reports

Rodríguez-Hidalgo M,Luna-Sánchez M,Hidalgo-Gutiérrez A,Barriocanal-Casado E,Mascaraque C,Acuña-Castroviejo D,Rivera M,Escames G,López LC

Tue Sep 18 00:00:00 UTC 2018

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Scientific reports

Rodríguez-Hidalgo M,Luna-Sánchez M,Hidalgo-Gutiérrez A,Barriocanal-Casado E,Mascaraque C,Acuña-Castroviejo D,Rivera M,Escames G,López LC

Tue Sep 18 00:00:00 UTC 2018

Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.

Journal of neurochemistry

Zhang L,Yang H,Zhang W,Liang Z,Huang Q,Xu G,Zhen X,Zheng LT

Tue Aug 01 00:00:00 UTC 2017

Detection of 6-demethoxyubiquinone in CoQ₁₀ deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Molecular genetics and metabolism

Herebian D,Seibt A,Smits SHJ,Bünning G,Freyer C,Prokisch H,Karall D,Wredenberg A,Wedell A,López LC,Mayatepek E,Distelmaier F

Sat Jul 01 00:00:00 UTC 2017

Detection of 6-demethoxyubiquinone in CoQ₁₀ deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Molecular genetics and metabolism

Herebian D,Seibt A,Smits SHJ,Bünning G,Freyer C,Prokisch H,Karall D,Wredenberg A,Wedell A,López LC,Mayatepek E,Distelmaier F

Sat Jul 01 00:00:00 UTC 2017

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death.

Molecular pharmacology

Yan Q,Han C,Wang G,Waddington JL,Zheng L,Zhen X

Fri Dec 01 00:00:00 UTC 2017

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death.

Molecular pharmacology

Yan Q,Han C,Wang G,Waddington JL,Zheng L,Zhen X

Fri Dec 01 00:00:00 UTC 2017

4-Hydroxybenzoic acid restores CoQ₁₀ biosynthesis in human COQ2 deficiency.

Annals of clinical and translational neurology

Herebian D,Seibt A,Smits SHJ,Rodenburg RJ,Mayatepek E,Distelmaier F

Fri Dec 01 00:00:00 UTC 2017

Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.

European journal of human genetics : EJHG

Danhauser K,Herebian D,Haack TB,Rodenburg RJ,Strom TM,Meitinger T,Klee D,Mayatepek E,Prokisch H,Distelmaier F

Tue Mar 01 00:00:00 UTC 2016

Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.

European journal of human genetics : EJHG

Danhauser K,Herebian D,Haack TB,Rodenburg RJ,Strom TM,Meitinger T,Klee D,Mayatepek E,Prokisch H,Distelmaier F

Tue Mar 01 00:00:00 UTC 2016

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nature cell biology

Monaghan RM,Barnes RG,Fisher K,Andreou T,Rooney N,Poulin GB,Whitmarsh AJ

Mon Jun 01 00:00:00 UTC 2015

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nature cell biology

Monaghan RM,Barnes RG,Fisher K,Andreou T,Rooney N,Poulin GB,Whitmarsh AJ

Mon Jun 01 00:00:00 UTC 2015

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nature cell biology

Monaghan RM,Barnes RG,Fisher K,Andreou T,Rooney N,Poulin GB,Whitmarsh AJ

Mon Jun 01 00:00:00 UTC 2015

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nature cell biology

Monaghan RM,Barnes RG,Fisher K,Andreou T,Rooney N,Poulin GB,Whitmarsh AJ

Mon Jun 01 00:00:00 UTC 2015

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.

The Journal of clinical investigation

Ashraf S,Gee HY,Woerner S,Xie LX,Vega-Warner V,Lovric S,Fang H,Song X,Cattran DC,Avila-Casado C,Paterson AD,Nitschké P,Bole-Feysot C,Cochat P,Esteve-Rudd J,Haberberger B,Allen SJ,Zhou W,Airik R,Otto EA,Barua M,Al-Hamed MH,Kari JA,Evans J,Bierzynska A,Saleem MA,Böckenhauer D,Kleta R,El Desoky S,Hacihamdioglu DO,Gok F,Washburn J,Wiggins RC,Choi M,Lifton RP,Levy S,Han Z,Salviati L,Prokisch H,Williams DS,Pollak M,Clarke CF,Pei Y,Antignac C,Hildebrandt F

Sun Dec 01 00:00:00 UTC 2013

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.

The Journal of clinical investigation

Sun Dec 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 5-demethoxyubiquinone hydroxylase; 5-demethoxyubiquinone hydroxylase, mitochondrial; Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7; coenzyme Q biosynthesis protein 7 homolog; coenzyme Q7 homolog, ubiquinone; COQ7 coenzyme Q, 7 homolog ubiquinone; demethyl-Q 7; DMQ hydroxylase; placental protein KG-20; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7; ubiquinone biosynthesis protein COQ7 homolog

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Gene Aliases: CAT5; CLK-1; CLK1; COQ10D8; COQ7

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UniProt ID: (Human) Q99807, (Mouse) P97478

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Entrez Gene ID: (Human) 10229, (Rat) 25249, (Mouse) 12850

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Function(s)

protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen metal ion binding molecular_function

Process(es)

age-dependent response to oxidative stress in utero embryonic development neural tube formation ubiquinone biosynthetic process response to oxidative stress determination of adult lifespan neurogenesis respiratory electron transport chain cellular response to oxidative stress response to drug mitochondrial ATP synthesis coupled electron transport oxidation-reduction process mitochondrion morphogenesis

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COQ7 Polyclonal Antibody

COQ7 Antibody (15083-1-AP) in IHC (P)

Product Details

15083-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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