Proteintech

CORO1C Polyclonal Antibody

CORO1C Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

CORO1C Antibody (14749-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CORO1C antibody 14749-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CORO1C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CORO1C Antibody in Immunoprecipitation (IP)

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Product Details

14749-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CORO1C Fusion Protein Ag6488 (1-306 aa encoded by BC002342)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRRVVRQSK FRHVFGQAVK NDQCYDDIRV SRVTWDSSFC AVNPRFVAII IEASGGGAFL VLPLHKTGRI DKSYPTVCGH TGPVLDIDWC PHNDQVIASG SEDCTVMVWQ IPENGLTLSL TEPVVILEGH SKRVGIVAWH PTARNVLLSA GCDNAIIIWN VGTGEALINL DDMHSDMIYN VSWNRNGSLI CTASKDKKVR VIDPRKQEIV AEKEKAHEGA RPMRAIFLAD GNVFTTGFSR MSERQLALWN PKNMQEPIAL HEMDTSNGVL LPFYDPDTSI IYLCGKGDSS IRYFEITDES PYVHYLN (1-306 aa encoded by BC002342)

Target Information

Coronin 3 is associated with the aggression and metastasis of hepatocellular carcinoma. Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.

Cell

Cui Q,Bi H,Lv Z,Wu Q,Hua J,Gu B,Huo C,Tang M,Chen Y,Chen C,Chen S,Zhang X,Wu Z,Lao Z,Sheng N,Shen C,Zhang Y,Wu ZY,Jin Z,Yang P,Liu H,Li J,Bai G

Thu Feb 16 00:00:00 UTC 2023

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.

Genes

Fukuda K,Seki N,Yasudome R,Mitsueda R,Asai S,Kato M,Idichi T,Kurahara H,Ohtsuka T

Thu Apr 27 00:00:00 UTC 2023

Coronin 1C restricts endosomal branched actin to organize ER contact and endosome fission.

The Journal of cell biology

Striepen JF,Voeltz GK

Mon Aug 01 00:00:00 UTC 2022

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer.

Frontiers in molecular biosciences

Wang Z,Jia L,Sun Y,Li C,Zhang L,Wang X,Chen H

Tue Apr 02 00:00:00 UTC 2024

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer.

Frontiers in molecular biosciences

Wang Z,Jia L,Sun Y,Li C,Zhang L,Wang X,Chen H

Tue Apr 02 00:00:00 UTC 2024

microRNA‑196a‑3p inhibits cell proliferation and promotes cell apoptosis by targeting ADP ribosylation factor 4 in diffuse large B‑cell lymphoma.

Oncology reports

Fu J,Lou X,Wan S,Zhao X,Chen Z,Zhu M,Guo L,Wu D,Wang S

Mon Feb 01 00:00:00 UTC 2021

microRNA‑196a‑3p inhibits cell proliferation and promotes cell apoptosis by targeting ADP ribosylation factor 4 in diffuse large B‑cell lymphoma.

Oncology reports

Fu J,Lou X,Wan S,Zhao X,Chen Z,Zhu M,Guo L,Wu D,Wang S

Mon Feb 01 00:00:00 UTC 2021

miR-26 suppresses renal cell cancer via down-regulating coronin-3.

Molecular and cellular biochemistry

Wang XJ,Yan ZJ,Luo GC,Chen YY,Bai PM

Wed Jan 01 00:00:00 UTC 2020

Silencing of MALAT1 inhibits migration and invasion by sponging miR‑1‑3p in prostate cancer cells.

Molecular medicine reports

Dai X,Liang Z,Liu L,Guo K,Xu S,Wang H

Tue Oct 01 00:00:00 UTC 2019

CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro.

FEBS open bio

Cheng X,Wang X,Wu Z,Tan S,Zhu T,Ding K

Sat Jun 01 00:00:00 UTC 2019

CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro.

FEBS open bio

Cheng X,Wang X,Wu Z,Tan S,Zhu T,Ding K

Sat Jun 01 00:00:00 UTC 2019

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission.

Cell

Hoyer MJ,Chitwood PJ,Ebmeier CC,Striepen JF,Qi RZ,Old WM,Voeltz GK

Thu Sep 20 00:00:00 UTC 2018

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission.

Cell

Hoyer MJ,Chitwood PJ,Ebmeier CC,Striepen JF,Qi RZ,Old WM,Voeltz GK

Thu Sep 20 00:00:00 UTC 2018

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.

Human molecular genetics

Pellegrini L,Hauser DN,Li Y,Mamais A,Beilina A,Kumaran R,Wetzel A,Nixon-Abell J,Heaton G,Rudenko I,Alkaslasi M,Ivanina N,Melrose HL,Cookson MR,Harvey K

Sat Sep 15 00:00:00 UTC 2018

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.

Human molecular genetics

Pellegrini L,Hauser DN,Li Y,Mamais A,Beilina A,Kumaran R,Wetzel A,Nixon-Abell J,Heaton G,Rudenko I,Alkaslasi M,Ivanina N,Melrose HL,Cookson MR,Harvey K

Sat Sep 15 00:00:00 UTC 2018

Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells.

Oncology reports

Wang ZG,Jia MK,Cao H,Bian P,Fang XD

Fri Mar 01 00:00:00 UTC 2013

Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.

Journal of experimental & clinical cancer research : CR

Wu L,Peng CW,Hou JX,Zhang YH,Chen C,Chen LD,Li Y

Wed Feb 24 00:00:00 UTC 2010

Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.

Journal of experimental & clinical cancer research : CR

Wu L,Peng CW,Hou JX,Zhang YH,Chen C,Chen LD,Li Y

Wed Feb 24 00:00:00 UTC 2010

Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.

Journal of experimental & clinical cancer research : CR

Wu L,Peng CW,Hou JX,Zhang YH,Chen C,Chen LD,Li Y

Wed Feb 24 00:00:00 UTC 2010

Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.

Journal of experimental & clinical cancer research : CR

Wu L,Peng CW,Hou JX,Zhang YH,Chen C,Chen LD,Li Y

Wed Feb 24 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: coronin 1c; coronin 3; coronin, actin binding protein, 1C; coronin, actin-binding protein, 1C; Coronin-1C; Coronin-3; hCRNN4

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Gene Aliases: AL022675; AW455561; AW548837; CORO1C; CRN2; CRNN4; HCRNN4; RGD1564490

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UniProt ID: (Human) Q9ULV4, (Mouse) Q9WUM4

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Entrez Gene ID: (Human) 23603, (Rat) 501841, (Mouse) 23790

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Function(s)

protein binding Rac GTPase binding actin filament binding actin binding

Process(es)

neural crest cell migration regulation of protein phosphorylation negative regulation of protein phosphorylation phagocytosis signal transduction regulation of epithelial cell migration negative regulation of epithelial cell migration regulation of fibroblast migration actin cytoskeleton organization negative regulation of protein kinase activity by regulation of protein phosphorylation establishment of protein localization regulation of focal adhesion assembly negative regulation of focal adhesion assembly activation of GTPase activity regulation of substrate adhesion-dependent cell spreading negative regulation of substrate adhesion-dependent cell spreading regulation of ruffle assembly positive regulation of lamellipodium morphogenesis actin cortical patch assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CORO1C Polyclonal Antibody

CORO1C Antibody (14749-1-AP) in ICC/IF

Product Details

14749-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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