Proteintech

COX-1/Cyclooxygenase-1 Polyclonal Antibody

COX-1/Cyclooxygenase-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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COX-1/Cyclooxygenase-1 Antibody (13393-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 13393-1-AP (COX-1/Cyclooxygenase-1 antibody at dilution of 1:200 (under 40x lens).

COX-1/Cyclooxygenase-1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

13393-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 17 publications 17 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PTGS1 Fusion Protein Ag4055

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

253 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study.

Nutrients

Šušnjara P,Mihaljević Z,Stupin A,Kolobarić N,Matić A,Jukić I,Kralik Z,Kralik G,Miloloža A,Pavošević T,Šerić V,Lončarić Z,Kerovec D,Galović O,Drenjančević I

Sat Mar 25 00:00:00 UTC 2023

Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells.

PloS one

Rood KM,Patel N,DeVengencie IM,Quinn JP,Gowdy KM,Costantine MM,Kniss DA

Thu Apr 27 00:00:00 UTC 2023

PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis.

Free radical biology & medicine

Sun Q,Shi L,Li S,Li J,Zhang R,Huang X,Shao Y,Feng Z,Peng Y,Yang Z,Liu J,Liu H,Long J

Sun Aug 20 00:00:00 UTC 2023

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zheng M,Hu Z,Wang Y,Wang C,Zhong C,Cui W,You J,Gao B,Sun X,La L

Sun Jan 01 00:00:00 UTC 2023

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zheng M,Hu Z,Wang Y,Wang C,Zhong C,Cui W,You J,Gao B,Sun X,La L

Sun Jan 01 00:00:00 UTC 2023

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zheng M,Hu Z,Wang Y,Wang C,Zhong C,Cui W,You J,Gao B,Sun X,La L

Sun Jan 01 00:00:00 UTC 2023

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zheng M,Hu Z,Wang Y,Wang C,Zhong C,Cui W,You J,Gao B,Sun X,La L

Sun Jan 01 00:00:00 UTC 2023

M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.

Small (Weinheim an der Bergstrasse, Germany)

Sun J,Ju F,Jin J,Wang HL,Li ZJ,Sun YC,Chen QZ,Yang QQ,Tan J,Zhou YL

Tue Aug 01 00:00:00 UTC 2023

Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.

Animals : an open access journal from MDPI

Li Y,Zhang G,Wen F,Xian M,Guo S,Zhang X,Feng X,Hu Z,Hu J

Sun Apr 23 00:00:00 UTC 2023

Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.

Animals : an open access journal from MDPI

Li Y,Zhang G,Wen F,Xian M,Guo S,Zhang X,Feng X,Hu Z,Hu J

Sun Apr 23 00:00:00 UTC 2023

Morphological changes of macrophages and their potential contribution to tendon healing.

Colloids and surfaces. B, Biointerfaces

Yang QQ,Zhang L,Zhou YL,Tang JB

Sat Jan 01 00:00:00 UTC 2022

Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries: role of oxidative stress.

American journal of physiology. Heart and circulatory physiology

Jukic I,Mihaljevic Z,Matic A,Mihalj M,Kozina N,Selthofer-Relatic K,Mihaljevic D,Koller A,Tartaro Bujak I,Drenjancevic I

Thu Apr 01 00:00:00 UTC 2021

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.

Acta pharmaceutica Sinica. B

Bakalarz D,Surmiak M,Yang X,Wójcik D,Korbut E,Śliwowski Z,Ginter G,Buszewicz G,Brzozowski T,Cieszkowski J,Głowacka U,Magierowska K,Pan Z,Wang B,Magierowski M

Mon Feb 01 00:00:00 UTC 2021

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.

Journal of molecular biology

Pacheu-Grau D,Wasilewski M,Oeljeklaus S,Gibhardt CS,Aich A,Chudenkova M,Dennerlein S,Deckers M,Bogeski I,Warscheid B,Chacinska A,Rehling P

Fri Mar 27 00:00:00 UTC 2020

Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.

Cells

Magierowska K,Bakalarz D,Wójcik D,Korbut E,Danielak A,Głowacka U,Pajdo R,Buszewicz G,Ginter G,Surmiak M,Kwiecień S,Chmura A,Magierowski M,Brzozowski T

Tue May 12 00:00:00 UTC 2020

Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation.

International journal of molecular sciences

Mihaljević Z,Matić A,Stupin A,Frkanec R,Tavčar B,Kelava V,Tartaro Bujak I,Kolobarić N,Kibel A,Drenjančević I

Tue Sep 01 00:00:00 UTC 2020

Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.

Inflammopharmacology

Chen J,Si M,Wang Y,Liu L,Zhang Y,Zhou A,Wei W

Fri Feb 01 00:00:00 UTC 2019

Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

Journal of ethnopharmacology

Yu HH,Lin Y,Zeng R,Li X,Zhang T,Tasneem S,Chen C,Qiu YX,Li B,Liao J,Wang YH,Cai X,Wang W

Fri Jun 28 00:00:00 UTC 2019

Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease.

Theranostics

Zhao J,Gao W,Cai X,Xu J,Zou D,Li Z,Hu B,Zheng Y

Thu Jun 18 00:00:00 UTC 2020

Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions.

Acta biomaterialia

Zhou YL,Yang QQ,Yan YY,Zhu C,Zhang L,Tang JB

Sun Apr 01 00:00:00 UTC 2018

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Mitochondrion

Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI

Thu Jan 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: COX-1; cyclooxygenase 3; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; PHS 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

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Gene Aliases: COI; Cox-1; Cox-3; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1

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UniProt ID: (Human) P23219, (Mouse) P22437

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Entrez Gene ID: (Human) 5742, (Rat) 24693, (Mouse) 19224

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Function(s)

peroxidase activity prostaglandin-endoperoxide synthase activity lipid binding heme binding metal ion binding dioxygenase activity oxidoreductase activity

Process(es)

prostaglandin biosynthetic process lipid metabolic process xenobiotic metabolic process inflammatory response response to oxidative stress aging learning memory regulation of blood pressure response to organonitrogen compound negative regulation of norepinephrine secretion sensory perception of pain cyclooxygenase pathway negative regulation of epinephrine secretion maintenance of blood-brain barrier regulation of cell proliferation positive regulation of vasoconstriction positive regulation of smooth muscle contraction response to corticosterone oxidation-reduction process response to fatty acid cellular oxidant detoxification prostaglandin metabolic process fatty acid metabolic process fatty acid biosynthetic process keratinocyte differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COX-1/Cyclooxygenase-1 Polyclonal Antibody

COX-1/Cyclooxygenase-1 Antibody (13393-1-AP) in IHC (P)

Product Details

13393-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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