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Invitrogen
COX1 Recombinant Rabbit Monoclonal Antibody (SC68-05)
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Product Details
MA5-32259
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SC68-05
Immunogen
Synthetic peptide within Human COX1 aa 116-159
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809545
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COX-1; cyclooxygenase 3; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; PHS 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene Aliases: COI; Cox-1; Cox-3; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219, (Mouse) P22437
Entrez Gene ID: (Human) 5742, (Rat) 24693, (Mouse) 19224
prostaglandin biosynthetic process
lipid metabolic process
xenobiotic metabolic process
inflammatory response
response to oxidative stress
aging
learning
memory
regulation of blood pressure
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
cyclooxygenase pathway
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
regulation of cell proliferation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
cellular oxidant detoxification
prostaglandin metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
keratinocyte differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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