Proteintech

COX5A Polyclonal Antibody

COX5A Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

COX5A Antibody (11448-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 11448-1-AP (COX5A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

COX5A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

11448-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chimpanzee, Human, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COX5A Fusion Protein Ag2005 (1-150 aa encoded by BC024240)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLGAALRRC AVAATTRADP RGLLHSARTP GPAVAIQSVR CYSHGSQETD EEFDARWVTY FNKPDIDAWE LRKGINTLVT YDMVPEPKII DAALRACRRL NDFASTVRIL EVVKDKAGPH KEIYPYVIQE LRPTLNELGI STPEELGLDK V (1-150 aa encoded by BC024240)

Target Information

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis.

Cell death & disease

Yang M,Liu K,Chen P,Zhu H,Wang J,Huang J

Sat Oct 29 00:00:00 UTC 2022

Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.

Frontiers in aging neuroscience

He K,Zhang J,Zhang W,Wang S,Li D,Ma X,Wu X,Chai X,Liu Q

Tue Mar 01 00:00:00 UTC 2022

Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.

Molecules (Basel, Switzerland)

Zou L,Bao W,Gao Y,Chen M,Wu Y,Wang S,Li C,Zhang J,Zhang D,Wang Q,Zhu A

Sun Oct 16 00:00:00 UTC 2022

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.

Human molecular genetics

Lin BC,Phung TH,Higgins NR,Greenslade JE,Prado MA,Finley D,Karbowski M,Polster BM,Monteiro MJ

Thu Jun 17 00:00:00 UTC 2021

Electroacupuncture Attenuates Ischemic Brain Injury and Cellular Apoptosis via Mitochondrial Translocation of Cofilin.

Chinese journal of integrative medicine

Chen B,Lin WQ,Li ZF,Zhong XY,Wang J,You XF,Zhao HJ,Qi DS

Wed Sep 01 00:00:00 UTC 2021

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Investigative ophthalmology & visual science

Jin X,Zhang J,Yi Q,Meng F,Yu J,Ji Y,Mo JQ,Tong Y,Jiang P,Guan MX

Tue Jun 01 00:00:00 UTC 2021

Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.

Nucleic acids research

Zhang Q,He X,Yao S,Lin T,Zhang L,Chen D,Chen C,Yang Q,Li F,Zhu YM,Guan MX

Fri May 07 00:00:00 UTC 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 UTC 2021

Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain.

Developmental cell

Krishna S,Arrojo E Drigo R,Capitanio JS,Ramachandra R,Ellisman M,Hetzer MW

Mon Nov 08 00:00:00 UTC 2021

Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.

Cardiovascular drugs and therapy

Wang Y,Wang Y,Li F,Zhang X,Li H,Yang G,Xu C,Wei C

Mon Feb 01 00:00:00 UTC 2021

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.

Nucleic acids research

Chen D,Zhang Z,Chen C,Yao S,Yang Q,Li F,He X,Ai C,Wang M,Guan MX

Tue Jun 04 00:00:00 UTC 2019

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 UTC 2017

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Cell death & disease

Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

Thu May 18 00:00:00 UTC 2017

Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.

PloS one

Gong YY,Liu YY,Li J,Su L,Yu S,Zhu XN,Cao XP,Xiao HP

Tue Sep 15 00:00:00 UTC 2015

Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.

PloS one

Gong YY,Liu YY,Li J,Su L,Yu S,Zhu XN,Cao XP,Xiao HP

Tue Sep 15 00:00:00 UTC 2015

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

The Journal of biological chemistry

Oliva CR,Nozell SE,Diers A,McClugage SG,Sarkaria JN,Markert JM,Darley-Usmar VM,Bailey SM,Gillespie GY,Landar A,Griguer CE

Fri Dec 17 00:00:00 UTC 2010

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

The Journal of biological chemistry

Oliva CR,Nozell SE,Diers A,McClugage SG,Sarkaria JN,Markert JM,Darley-Usmar VM,Bailey SM,Gillespie GY,Landar A,Griguer CE

Fri Dec 17 00:00:00 UTC 2010

Diagnostic biomarkers for renal cell carcinoma: selection using novel bioinformatics systems for microarray data analysis.

Human pathology

Osunkoya AO,Yin-Goen Q,Phan JH,Moffitt RA,Stokes TH,Wang MD,Young AN

Tue Dec 01 00:00:00 UTC 2009

Diagnostic biomarkers for renal cell carcinoma: selection using novel bioinformatics systems for microarray data analysis.

Human pathology

Osunkoya AO,Yin-Goen Q,Phan JH,Moffitt RA,Stokes TH,Wang MD,Young AN

Tue Dec 01 00:00:00 UTC 2009

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

BMC evolutionary biology

Uddin M,Opazo JC,Wildman DE,Sherwood CC,Hof PR,Goodman M,Grossman LI

Tue Jan 15 00:00:00 UTC 2008

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

BMC evolutionary biology

Uddin M,Opazo JC,Wildman DE,Sherwood CC,Hof PR,Goodman M,Grossman LI

Tue Jan 15 00:00:00 UTC 2008

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

BMC evolutionary biology

Uddin M,Opazo JC,Wildman DE,Sherwood CC,Hof PR,Goodman M,Grossman LI

Tue Jan 15 00:00:00 UTC 2008

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

BMC evolutionary biology

Uddin M,Opazo JC,Wildman DE,Sherwood CC,Hof PR,Goodman M,Grossman LI

Tue Jan 15 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: Cytochrome c oxidase polypeptide Va; cytochrome c oxidase polypeptide, mitochondrial; Cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase subunit Va; mitochondrial cytochrome c oxidase subunit Va

View more View less

Gene Aliases: AA959768; CcOX; COX; COX-VA; COX5A; VA

View more View less

UniProt ID: (Human) P20674, (Rat) P11240, (Mouse) P12787

View more View less

Entrez Gene ID: (Human) 9377, (Rat) 252934, (Mouse) 12858

View more View less

Function(s)

cytochrome-c oxidase activity protein binding electron carrier activity metal ion binding

Process(es)

mitochondrial electron transport, cytochrome c to oxygen hydrogen ion transmembrane transport oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

COX5A Polyclonal Antibody

COX5A Antibody (11448-1-AP) in ICC/IF

Product Details

11448-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!