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COX6A1 Polyclonal Antibody

COX6A1 Antibody in Immunocytochemistry (ICC/IF)

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COX6A1 Antibody (11460-1-AP) in ICC/IF

Immunofluorescent analysis of (10% Formaldehyde) fixed MCF-7 cells using (Product # 11460-1-AP) (COX6A1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

COX6A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

11460-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COX6A1 Fusion Protein Ag2006 (1-109 aa encoded by BC007723)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAVVGVSSV SRLLGRSRPQ LGRPMSSGAH GEEGSARMWK TLTFFVALPG VAVSMLNVYL KSHHGEHERP EFIAYPHLRI RTKPFPWGDG NHTLFHNPHV NPLPTGYEDE (1-109 aa encoded by BC007723)

Target Information

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Switching ubiquitous and muscle-specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine-tunes complex IV activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ye X,Xie Y,Shi Y,Wang B,Han X,Zhou X,Pan K,Wang M,Fang H

Sat Apr 01 00:00:00 UTC 2023

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Cell reports

Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G

Tue Mar 08 00:00:00 UTC 2022

Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation.

Human molecular genetics

Kee TR,Wehinger JL,Gonzalez PE,Nguyen E,McGill Percy KC,Khan SA,Chaput D,Wang X,Liu T,Kang DE,Woo JA

Mon Nov 28 00:00:00 UTC 2022

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).

Autophagy

Luo P,Yan H,Du J,Chen X,Shao J,Zhang Y,Xu Z,Jin Y,Lin N,Yang B,He Q

Fri Oct 01 00:00:00 UTC 2021

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).

Autophagy

Luo P,Yan H,Du J,Chen X,Shao J,Zhang Y,Xu Z,Jin Y,Lin N,Yang B,He Q

Fri Oct 01 00:00:00 UTC 2021

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).

Autophagy

Luo P,Yan H,Du J,Chen X,Shao J,Zhang Y,Xu Z,Jin Y,Lin N,Yang B,He Q

Fri Oct 01 00:00:00 UTC 2021

PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).

Autophagy

Luo P,Yan H,Du J,Chen X,Shao J,Zhang Y,Xu Z,Jin Y,Lin N,Yang B,He Q

Fri Oct 01 00:00:00 UTC 2021

HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.

Molecular & cellular proteomics : MCP

Hock DH,Reljic B,Ang CS,Muellner-Wong L,Mountford HS,Compton AG,Ryan MT,Thorburn DR,Stroud DA

Wed Jul 01 00:00:00 UTC 2020

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.

eLife

Kang Y,Anderson AJ,Jackson TD,Palmer CS,De Souza DP,Fujihara KM,Stait T,Frazier AE,Clemons NJ,Tull D,Thorburn DR,McConville MJ,Ryan MT,Stroud DA,Stojanovski D

Mon Nov 04 00:00:00 UTC 2019

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.

Cell death & disease

Wu W,Zheng X,Wang J,Yang T,Dai W,Song S,Fang L,Wang Y,Gu J

Thu Sep 20 00:00:00 UTC 2018

Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.

PloS one

Huang R,Zhao L,Chen H,Yin RH,Li CY,Zhan YQ,Zhang JH,Ge CH,Yu M,Yang XM

Mon Oct 19 00:00:00 UTC 2015

Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.

PloS one

Huang R,Zhao L,Chen H,Yin RH,Li CY,Zhan YQ,Zhang JH,Ge CH,Yu M,Yang XM

Mon Oct 19 00:00:00 UTC 2015

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

The Journal of biological chemistry

Oliva CR,Nozell SE,Diers A,McClugage SG,Sarkaria JN,Markert JM,Darley-Usmar VM,Bailey SM,Gillespie GY,Landar A,Griguer CE

Fri Dec 17 00:00:00 UTC 2010

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

The Journal of biological chemistry

Oliva CR,Nozell SE,Diers A,McClugage SG,Sarkaria JN,Markert JM,Darley-Usmar VM,Bailey SM,Gillespie GY,Landar A,Griguer CE

Fri Dec 17 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: COX VIa-L; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit 6A1, mitochondrial; Cytochrome c oxidase subunit VIa (liver); cytochrome C oxidase subunit VIa homolog; cytochrome c oxidase subunit VIa polypeptide 1; Cytochrome c oxidase subunit VIA-liver; subunit VIaL (liver-type)

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Gene Aliases: CMTRID; COX6A; COX6A1; COX6AL; VIaL

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UniProt ID: (Human) P12074, (Mouse) P43024, (Rat) P10818

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Entrez Gene ID: (Human) 1337, (Mouse) 12861, (Rat) 25282

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Function(s)

cytochrome-c oxidase activity

Process(es)

hydrogen ion transmembrane transport generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COX6A1 Polyclonal Antibody

COX6A1 Antibody (11460-1-AP) in ICC/IF

Product Details

11460-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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