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Proteintech
CP110 Monoclonal Antibody (1A3C12)
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Product Details
66448-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1A3C12
Immunogen
CP110 Fusion Protein Ag3489 (1-337 aa encoded by BC036654)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEEYEKFCE KSLARIQEAS LSTESFLPAQ SESISLIRFH GVAILSPLLN IEKRKEMQQE KQKALDVEAR KQVNRKKALL TRVQEILDNV QVRKAPNASD FDQWEMETVY SNSEVRNLNV PATFPNSFPS HTEHSTAAKL DKIAGILPLD NEDQCKTDGI DLARDSEGFN SPKQCDSSNI SHVENEAFPK TSSATPQETL ISDGPFSVNE QQDLPLLAEV IPDPYVMSLQ NLMKKSKEYI EREQSRRSLR GSMNRIVNES HLDKEHDAVE VADCVKEKGQ LTGKHCVSVI PDKPSLNKSN VLLQGASTQA SSMSMPVLAS FSKVDIPIRT GHPTVLES (1-337 aa encoded by BC036654)
Target Information
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: centriolar coiled coil protein 110kDa; centriolar coiled-coil protein 110kDa; Centriolar coiled-coil protein of 110 kDa; Centriolin; centrosomal protein CP110; Centrosomal protein of 110 kDa; CEP1; CNTRL; CP110; FAN
Gene Aliases: CCP110; CEP110; CP110; KIAA0419
UniProt ID: (Human) O43303
Entrez Gene ID: (Human) 9738
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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