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Invitrogen
CPAMD8 Polyclonal Antibody
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Product Details
PA5-56706
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CPAMD8. Recombinant protein control fragment (Product #RP-102590).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2640113
Product Specific Information
Immunogen sequence: FPETWIWHCL NISDPSGEGT LSVKVPDSIT SWVGEAVALS TSQGLGIAEP SLLKTFKPFF VDFMLPALII RGEQVKIPLS VYNYMGTCAE VYMKLSVPK
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 42%.
Target Information
The CPAMD8 gene, known as C3 and pregnancy zone protein-like alpha-2-macroglobulin domain-containing 8, is involved in the development of ocular tissues. It has been linked to anterior segment dysgenesis (ASD) and congenital glaucoma, indicating its critical role in eye development. CPAMD8 functions primarily within the non-pigmented epithelium and might participate in cellular communication and structural integrity during the differentiation of retinal organoids. Loss-of-function mutations in CPAMD8 disrupt normal eye formation, leading to various ocular disorders. Recent advancements, such as the establishment of CPAMD8-GFP reporter human embryonic stem cell lines, enable real-time monitoring of its expression, thereby facilitating exploration of its biological functions in retinal differentiation processes. Bioinformatic evaluations and CRISPR/Cas9 technology have provided insights into CPAMD8's role in eye development, with gene editing approaches helping delineate its involvement in ocular health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2 macroglobulin family protein VIP; C3 and PZP-like, alpha-2-macroglobulin domain containing 8
Gene Aliases: K-CAP; VIP
Entrez Gene ID: (Human) 27151
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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