Proteintech

CPEB1 Polyclonal Antibody

CPEB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CPEB1 Antibody (13274-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 13274-1-AP ( CPEB1 Antibody) at dilution of 1:50 (under 40x lens).

Product Image Gallery

Product Details

13274-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Echinoderm, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CPEB1 Fusion Protein Ag3994 (188-486 aa encoded by BC035348)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody may recognize several bands, but only ~56 kDa band is the right one, other (40~50 kDa) is un-specific bands.

Immunogen sequence: WDLLEAPKD PFSIEREARL HRQAAAVNEA TCTWSGQLPP RNYKNPIYSC KVFLGGVPWD ITEAGLVNTF RVFGSLSVEW PGKDGKHPRC PPKGYVYLVF ELEKSVRSLL QACSHDPLSP DGLSEYYFKM SSRRMRCKEV QVIPWVLADS NFVRSPSQRL DPSRTVFVGA LHGMLNAEAL AAILNDLFGG VVYAGIDTDK HKYPIGSGRV TFNNQRSYLK AVSAAFVEIK TTKFTKKVQI DPYLEDSLCH ICSSQPGPFF CRDQVCFKYF CRSCWHWRHS MEGLRHHSPL MRNQKNRDSS (188-486 aa encoded by BC035348)

Target Information

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the nuclear membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the nuclear membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.

bioRxiv : the preprint server for biology

Chen CC,Han J,Chinn CA,Rounds JS,Li X,Nikan M,Myszka M,Tong L,Passalacqua LFM,Bredy TW,Wood MA,Lupták A

Fri Jun 09 00:00:00 UTC 2023

Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Guo J,Zhao H,Zhang J,Lv X,Zhang S,Su R,Zheng W,Dai J,Meng F,Gong F,Lu G,Xue Y,Lin G

Sat Apr 01 00:00:00 UTC 2023

Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer.

Frontiers in immunology

Zhou Y,Xiao L,Long G,Cao J,Liu S,Tao Y,Zhou L,Tang J

Fri Sep 09 00:00:00 UTC 2022

Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development.

Nature cell biology

Xiong Z,Xu K,Lin Z,Kong F,Wang Q,Quan Y,Sha QQ,Li F,Zou Z,Liu L,Ji S,Chen Y,Zhang H,Fang J,Yu G,Liu B,Wang L,Wang H,Deng H,Yang X,Fan HY,Li L,Xie W

Wed Jun 01 00:00:00 UTC 2022

MicroRNA-455-5p/CPEB1 pathway mediates Aβ-related learning and memory deficits in a mouse model of Alzheimer's disease.

Brain research bulletin

Xiao G,Chen Q,Zhang X

Wed Dec 01 00:00:00 UTC 2021

MicroRNA-455-5p/CPEB1 pathway mediates Aβ-related learning and memory deficits in a mouse model of Alzheimer's disease.

Brain research bulletin

Xiao G,Chen Q,Zhang X

Wed Dec 01 00:00:00 UTC 2021

L-bodies are RNA-protein condensates driving RNA localization in Xenopus oocytes.

Molecular biology of the cell

Neil CR,Jeschonek SP,Cabral SE,O'Connell LC,Powrie EA,Otis JP,Wood TR,Mowry KL

Wed Dec 01 00:00:00 UTC 2021

mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4.

RNA (New York, N.Y.)

Pascual R,Segura-Morales C,Omerzu M,Bellora N,Belloc E,Castellazzi CL,Reina O,Eyras E,Maurice MM,Millanes-Romero A,Méndez R

Tue Dec 15 00:00:00 UTC 2020

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

Nature

Parras A,Anta H,Santos-Galindo M,Swarup V,Elorza A,Nieto-González JL,Picó S,Hernández IH,Díaz-Hernández JI,Belloc E,Rodolosse A,Parikshak NN,Peñagarikano O,Fernández-Chacón R,Irimia M,Navarro P,Geschwind DH,Méndez R,Lucas JJ

Wed Aug 01 00:00:00 UTC 2018

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

Nature

Wed Aug 01 00:00:00 UTC 2018

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

Nature

Wed Aug 01 00:00:00 UTC 2018

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins.

Nucleic acids research

Chen J,Cai T,Zheng C,Lin X,Wang G,Liao S,Wang X,Gan H,Zhang D,Hu X,Wang S,Li Z,Feng Y,Yang F,Han C

Thu Apr 20 00:00:00 UTC 2017

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins.

Nucleic acids research

Chen J,Cai T,Zheng C,Lin X,Wang G,Liao S,Wang X,Gan H,Zhang D,Hu X,Wang S,Li Z,Feng Y,Yang F,Han C

Thu Apr 20 00:00:00 UTC 2017

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins.

Nucleic acids research

Chen J,Cai T,Zheng C,Lin X,Wang G,Liao S,Wang X,Gan H,Zhang D,Hu X,Wang S,Li Z,Feng Y,Yang F,Han C

Thu Apr 20 00:00:00 UTC 2017

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins.

Nucleic acids research

Chen J,Cai T,Zheng C,Lin X,Wang G,Liao S,Wang X,Gan H,Zhang D,Hu X,Wang S,Li Z,Feng Y,Yang F,Han C

Thu Apr 20 00:00:00 UTC 2017

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

Frontiers in molecular neuroscience

Lou WP,Mateos A,Koch M,Klussman S,Yang C,Lu N,Kumar S,Limpert S,Göpferich M,Zschaetzsch M,Sliwinski C,Kenzelmann M,Seedorf M,Maillo C,Senis E,Grimm D,Puttagunta R,Mendez R,Liu K,Hassan BA,Martin-Villalba A

Wed Mar 13 00:00:00 UTC 2024

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

Frontiers in molecular neuroscience

Wed Mar 13 00:00:00 UTC 2024

Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies.

Nature communications

Villanueva E,Navarro P,Rovira-Rigau M,Sibilio A,Méndez R,Fillat C

Thu Mar 16 00:00:00 UTC 2017

Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies.

Nature communications

Villanueva E,Navarro P,Rovira-Rigau M,Sibilio A,Méndez R,Fillat C

Thu Mar 16 00:00:00 UTC 2017

Block of CDK1-dependent polyadenosine elongation of Cyclin B mRNA in metaphase-i-arrested starfish oocytes is released by intracellular pH elevation upon spawning.

Molecular reproduction and development

Ochi H,Aoto S,Tachibana K,Hara M,Chiba K

Fri Jan 01 00:00:00 UTC 2016

Block of CDK1-dependent polyadenosine elongation of Cyclin B mRNA in metaphase-i-arrested starfish oocytes is released by intracellular pH elevation upon spawning.

Molecular reproduction and development

Ochi H,Aoto S,Tachibana K,Hara M,Chiba K

Fri Jan 01 00:00:00 UTC 2016

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.

Gastroenterology