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Product Details
H00008904-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
8B8
Immunogen
CPNE1 (NP_003906, 111 a.a. approximately 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: TLPLMLKPGK PAGRGTITVS AQELKDNRVV TMEVEARNLD KKDFLGKSDP FLEFFRQGDG KWHLVYRSEV IKNNLNPTWK RFSVPVQHFC GGNPSTPIQV
Target Information
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromobindin 17; Copine I; Copine-1; MGC1142; OTTHUMP00000030775; OTTHUMP00000030776
Gene Aliases: COPN1; CPN1; CPNE1
UniProt ID: (Human) Q99829
Entrez Gene ID: (Human) 8904
transcription, DNA-templated
regulation of transcription, DNA-templated
proteolysis
lipid metabolic process
negative regulation of gene expression
vesicle-mediated transport
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of DNA binding
positive regulation of neuron differentiation
glycerophospholipid biosynthetic process
positive regulation of protein kinase B signaling
cellular response to calcium ion
negative regulation of NIK/NF-kappaB signaling
positive regulation of tumor necrosis factor-mediated signaling pathway
neuron projection extension
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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