Proteintech

CPOX Polyclonal Antibody

CPOX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CPOX Antibody (12211-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 12211-1-AP) (CPOX antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CPOX Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12211-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CPOX Fusion Protein Ag2858 (1-303 aa encoded by BC023551)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MALQLGRLS SGPCWLVARG GCGGPRAWSQ CGGGGLRAWS QRSAAGRVCR PPGPAGTEQS RGLGHGSTSR GGPWVGTGLA AALAGLVGLA TAAFGHVQRA EMLPKTSGTR ATSLGRPEEE EDELAHRCSS FMAPPVTDLG ELRRRPGDMK TKMELLILET QAQVCQALAQ VDGGANFSVD RWERKEGGGG ISCVLQDGCV FEKAGVSISV VHGNLSEEAA KQMRSRGKVL KTKDGKLPFC AMGVSSVIHP KNPHAPTIHF NYRYFEVEEA DGNKQWWFGG GCDLTPTYLN QEDAVHFHRT LKEA (1-303 aa encoded by BC023551)

Target Information

The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas.

Frontiers in medicine

Mischkulnig M,Roetzer-Pejrimovsky T,Lötsch-Gojo D,Kastner N,Bruckner K,Prihoda R,Lang A,Martinez-Moreno M,Furtner J,Berghoff A,Woehrer A,Berger W,Widhalm G,Kiesel B

Sat Jul 16 00:00:00 UTC 2022

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.

The Journal of cell biology

Oshima Y,Cartier E,Boyman L,Verhoeven N,Polster BM,Huang W,Kane M,Lederer WJ,Karbowski M

Mon Jun 07 00:00:00 UTC 2021

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.

The Journal of cell biology

Oshima Y,Cartier E,Boyman L,Verhoeven N,Polster BM,Huang W,Kane M,Lederer WJ,Karbowski M

Mon Jun 07 00:00:00 UTC 2021

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.

Cell reports

Acoba MG,Alpergin ESS,Renuse S,Fernández-Del-Río L,Lu YW,Khalimonchuk O,Clarke CF,Pandey A,Wolfgang MJ,Claypool SM

Tue Mar 16 00:00:00 UTC 2021

Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis.

Biochemical pharmacology

Módis K,Ramanujam VS,Govar AA,Lopez E,Anderson KE,Wang R,Szabo C

Fri Nov 01 00:00:00 UTC 2019

Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.

Photodiagnosis and photodynamic therapy

Kurumi H,Kanda T,Kawaguchi K,Yashima K,Koda H,Ogihara K,Matsushima K,Nakao K,Saito H,Fujiwara Y,Osaki M,Okada F,Isomoto H

Fri Jun 01 00:00:00 UTC 2018

Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.

Photodiagnosis and photodynamic therapy

Kurumi H,Kanda T,Kawaguchi K,Yashima K,Koda H,Ogihara K,Matsushima K,Nakao K,Saito H,Fujiwara Y,Osaki M,Okada F,Isomoto H

Fri Jun 01 00:00:00 UTC 2018

Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis.

Photodiagnosis and photodynamic therapy

Ogihara K,Isomoto H,Kurumi H,Kanda T,Hashisako M,Tabata K,Ishii H,Ohnita K,Yamaguchi N,Akazawa Y,Matsushima K,Takeshima F,Kunizaki M,Hidaka S,Nanashima A,Fukuoka J,Nagayasu T,Nakao K

Fri Sep 01 00:00:00 UTC 2017

Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis.

Photodiagnosis and photodynamic therapy

Ogihara K,Isomoto H,Kurumi H,Kanda T,Hashisako M,Tabata K,Ishii H,Ohnita K,Yamaguchi N,Akazawa Y,Matsushima K,Takeshima F,Kunizaki M,Hidaka S,Nanashima A,Fukuoka J,Nagayasu T,Nakao K

Fri Sep 01 00:00:00 UTC 2017

Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-induced fluorescence.

Neuro-oncology

Takahashi K,Ikeda N,Nonoguchi N,Kajimoto Y,Miyatake S,Hagiya Y,Ogura S,Nakagawa H,Ishikawa T,Kuroiwa T

Tue Nov 01 00:00:00 UTC 2011

Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-induced fluorescence.

Neuro-oncology

Takahashi K,Ikeda N,Nonoguchi N,Kajimoto Y,Miyatake S,Hagiya Y,Ogura S,Nakagawa H,Ishikawa T,Kuroiwa T

Tue Nov 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: clone 560; coprogen oxidase; Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX); coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; COX; cpox {ECO:0000312|EMBL:AAI07665.1}; Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

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Gene Aliases: cac; CPO; CPOX; CPX; HCP; nct

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UniProt ID: (Human) P36551, (Rat) Q3B7D0, (Mouse) P36552

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Entrez Gene ID: (Human) 1371, (Rat) 304024, (Mouse) 12892

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Function(s)

coproporphyrinogen oxidase activity structural constituent of eye lens protein homodimerization activity identical protein binding sodium:potassium-exchanging ATPase activity oxidoreductase activity

Process(es)

protoporphyrinogen IX biosynthetic process heme biosynthetic process response to inorganic substance response to iron ion response to lead ion response to insecticide response to arsenic-containing substance response to methylmercury oxidation-reduction process porphyrin-containing compound biosynthetic process potassium ion transport sodium ion transport sodium ion transmembrane transport potassium ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CPOX Polyclonal Antibody

CPOX Antibody (12211-1-AP) in IHC (P)

Product Details

12211-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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