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Proteintech
CPSF1 Polyclonal Antibody
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Product Details
11031-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CPSF1 Fusion Protein Ag1489 (1039-1443 aa encoded by BC017232)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STNTPCARI PRMTGEEKEF ETIERDERYI HPQQEAFSIQ LISPVSWEAI PNARIELQEW EHVTCMKTVS LRSEETVSGL KGYVAAGTCL MQGEEVTCRG RILIMDVIEV VPEPGQPLTK NKFKVLYEKE QKGPVTALCH CNGHLVSAIG QKIFLWSLRA SELTGMAFID TQLYIHQMIS VKNFILAADV MKSISLLRYQ EESKTLSLVS RDAKPLEVYS VDFMVDNAQL GFLVSDRDRN LMVYMYLPEA KESFGGMRLL RRADFHVGAH VNTFWRTPCR GATEGLSKKS VVWENKHITW FATLDGGIGL LLPMQEKTYR RLLMLQNALT TMLPHHAGLN PRAFRMLHVD RRTLQNAVRN VLDGELLNRY LYLSTMERSE LAKKIGTTPD IILDDLLETD RVTAHF (1039-1443 aa encoded by BC017232)
Target Information
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cleavage and polyadenylation specific factor 1, 160kDa; Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; polyadenylation specificity factor
Gene Aliases: CPSF1; CPSF160; HSU37012; P/cl.18
UniProt ID: (Human) Q10570
Entrez Gene ID: (Human) 29894
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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