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Invitrogen
CPT1A Polyclonal Antibody
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FIGURE: 1 / 7
CPT1A Antibody (PA5-76788) in ICC/IF
Immunofluorescence analysis of Carnitine O-palmitoyl transferase 1, liver isoform was performed using 70% confluent log phase MCF7 and MCF 10A cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with CPT1A Polyclonal Antibody (Product # PA5-76788) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed... View More
Product Details
PA5-76788
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human CPT1A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2720515
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Carnitine O-palmitoyltransferase 1, liver isoform; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1 alpha, liver isoform; carnitine palmitoyltransferase 1, liver; Carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT 1; CPT I; CPT1 L; CPT1-L; CPTI-L; L-CPT I; Succinyltransferase CPT1A
Gene Aliases: C730027G07; Cpt-1; CPT-Ia; CPT1; CPT1-L; CPT1A; CPTI; L-CPT1
UniProt ID: (Human) P50416, (Mouse) P97742, (Rat) P32198
Entrez Gene ID: (Human) 1374, (Mouse) 12894, (Rat) 25757
long-chain fatty acid metabolic process
glucose metabolic process
lipid metabolic process
fatty acid metabolic process
triglyceride metabolic process
transport
carnitine metabolic process
positive regulation of fatty acid beta-oxidation
eating behavior
regulation of fatty acid oxidation
regulation of insulin secretion
protein homooligomerization
fatty acid beta-oxidation
carnitine shuttle
circadian rhythm
response to organic cyclic compound
epithelial cell differentiation
response to drug
cellular response to fatty acid
regulation of fatty acid beta-oxidation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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