Proteintech

CPT1A Monoclonal Antibody (5D8G9)

CPT1A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CPT1A Antibody (66039-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue slide using (Product # 66039-1-Ig) CPT1A antibody at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CPT1A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

66039-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

5D8G9

Immunogen

CPT1A Fusion Protein Ag7745 (406-756 aa encoded by BC000185)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.59 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can bind the close sequences genes.

Immunogen sequence: QSLDAVEKA AFFVTLDETE EGYRSEDPDT SMDSYAKSLL HGRCYDRWFD KSFTFVVFKN GKMGLNAEHS WADAPIVAHL WEYVMSIDSL QLGYAEDGHC KGDINPNIPY PTRLQWDIPG ECQEVIETSL NTANLLANDV DFHSFPFVAF GKGIIKKCRT SPDAFVQLAL QLAHYKDMGK FCLTYEASMT RLFREGRTET VRSCTTESCD FVRAMVDPAQ TVEQRLKLFK LASEKHQHMY RLAMTGSGID RHLFCLYVVS KYLAVESPFL KEVLSEPWRL STSQTPQQQV ELFDLENNPE YVSSGGGFGP VADDGYGVSY ILVGENLINF HISSKFSCPE TGIISQGPSS DT (406-756 aa encoded by BC000185)

Target Information

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways.

Acta physiologica (Oxford, England)

Li S,Liu M,Chen J,Chen Y,Yin M,Zhou Y,Li Q,Xu F,Li Y,Yan X,Xia Y,Chen A,Lu D,Li C,Shen L,Chen Z,Qian J,Ge J

Sat Jul 01 00:00:00 UTC 2023

L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways.

Acta physiologica (Oxford, England)

Li S,Liu M,Chen J,Chen Y,Yin M,Zhou Y,Li Q,Xu F,Li Y,Yan X,Xia Y,Chen A,Lu D,Li C,Shen L,Chen Z,Qian J,Ge J

Sat Jul 01 00:00:00 UTC 2023

Impaired FXR-CPT1a signaling contributes to parenteral nutrition-induced villus atrophy in short-bowel syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhao Y,Feng H,Wang Y,Jiang L,Yan J,Cai W

Sun Jan 01 00:00:00 UTC 2023

Impaired FXR-CPT1a signaling contributes to parenteral nutrition-induced villus atrophy in short-bowel syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhao Y,Feng H,Wang Y,Jiang L,Yan J,Cai W

Sun Jan 01 00:00:00 UTC 2023

PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation.

Nature metabolism

Wu D,Hu L,Han M,Deng Y,Zhang Y,Ren G,Zhao X,Li Z,Li P,Zhang Y,Chen S,Li J,Shi Y,Xue J,Wang P,Zhong C

Fri Jul 01 00:00:00 UTC 2022

PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation.

Nature metabolism

Wu D,Hu L,Han M,Deng Y,Zhang Y,Ren G,Zhao X,Li Z,Li P,Zhang Y,Chen S,Li J,Shi Y,Xue J,Wang P,Zhong C

Fri Jul 01 00:00:00 UTC 2022

Lipidomics reveals the potential mechanism of honokiol against adenine-induced chronic kidney disease.

Frontiers in pharmacology

Liu X,Gao L,Huang X,Deng R,Wei X,Lu J,Li S

Wed Nov 02 00:00:00 UTC 2022

Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.

Food & function

Tao W,Cao W,Yu B,Chen H,Gong R,Luorong Q,Luo J,Yao L,Zhang D

Mon Jun 06 00:00:00 UTC 2022

Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.

Food & function

Tao W,Cao W,Yu B,Chen H,Gong R,Luorong Q,Luo J,Yao L,Zhang D

Mon Jun 06 00:00:00 UTC 2022

Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.

Frontiers in pharmacology

Yang S,Cao S,Li C,Zhang J,Liu C,Qiu F,Kang N

Tue Jul 26 00:00:00 UTC 2022

The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m⁶A RNA methylation reading protein Ythdf2.

Cell death discovery

Yang Y,Mbikyo MB,Zhang J,Zhang Y,Zhang N,Li Z

Tue Apr 05 00:00:00 UTC 2022

The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m⁶A RNA methylation reading protein Ythdf2.

Cell death discovery

Yang Y,Mbikyo MB,Zhang J,Zhang Y,Zhang N,Li Z

Tue Apr 05 00:00:00 UTC 2022

Altered Peroxisome Proliferator-Activated Receptor Alpha Signaling in Variably Diseased Peripheral Arterial Segments.

Frontiers in cardiovascular medicine

Engel C,Meade R,Harroun N,Penrose A,Shafqat M,Jin X,DeSilva G,Semenkovich C,Zayed M

Wed Feb 15 00:00:00 UTC 2023

MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.

Cancer & metabolism

Zhang T,Zhang Y,Liu J,Ma Y,Ye Q,Yan X,Ding L

Thu Jan 20 00:00:00 UTC 2022

The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury.

Frontiers in pharmacology

Ma Y,Wang M,Guo S,Li T,Liu X,Zhao L

Sat Nov 26 00:00:00 UTC 2022

CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα.

Diabetes

Zayed MA,Jin X,Yang C,Belaygorod L,Engel C,Desai K,Harroun N,Saffaf O,Patterson BW,Hsu FF,Semenkovich CF

Mon Feb 01 00:00:00 UTC 2021

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Frontiers in oncology

Lu J,Zhang Y,Sun M,Ding C,Zhang L,Kong Y,Cai M,Miccoli P,Ma C,Yue X

Fri Apr 29 00:00:00 UTC 2022

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Frontiers in oncology

Lu J,Zhang Y,Sun M,Ding C,Zhang L,Kong Y,Cai M,Miccoli P,Ma C,Yue X

Fri Apr 29 00:00:00 UTC 2022

Etomoxir regulates the differentiation of male germ cells by specifically reducing H3K27ac level.

BMC developmental biology

Xu Y,Xie J

Mon Feb 01 00:00:00 UTC 2021

Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment.

Food & function

Man S,Yao J,Lv P,Liu Y,Yang L,Ma L

Wed Jul 22 00:00:00 UTC 2020

Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients.

Molecular bioSystems

Li L,Wang C,Yang H,Liu S,Lu Y,Fu P,Liu J

Tue Oct 24 00:00:00 UTC 2017

Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients.

Molecular bioSystems

Li L,Wang C,Yang H,Liu S,Lu Y,Fu P,Liu J

Tue Oct 24 00:00:00 UTC 2017

Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.

PloS one

Vancura P,Wolloscheck T,Baba K,Tosini G,Iuvone PM,Spessert R

Tue May 09 00:00:00 UTC 2017

Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.

PloS one

Vancura P,Wolloscheck T,Baba K,Tosini G,Iuvone PM,Spessert R

Tue May 09 00:00:00 UTC 2017

Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.

PloS one

Vancura P,Wolloscheck T,Baba K,Tosini G,Iuvone PM,Spessert R

Tue May 09 00:00:00 UTC 2017

Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.

PloS one

Vancura P,Wolloscheck T,Baba K,Tosini G,Iuvone PM,Spessert R

Tue May 09 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Carnitine O-palmitoyltransferase 1, liver isoform; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1 alpha, liver isoform; carnitine palmitoyltransferase 1, liver; Carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT 1; CPT I; CPT1 L; CPT1-L; CPTI-L; L-CPT I; Succinyltransferase CPT1A

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Gene Aliases: C730027G07; Cpt-1; CPT-Ia; CPT1; CPT1-L; CPT1A; CPTI; L-CPT1

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UniProt ID: (Human) P50416, (Mouse) P97742, (Rat) P32198

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Entrez Gene ID: (Human) 1374, (Mouse) 12894, (Rat) 25757

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Function(s)

carnitine O-palmitoyltransferase activity identical protein binding palmitoleoyltransferase activity transferase activity transferase activity, transferring acyl groups protein binding

Process(es)

long-chain fatty acid metabolic process glucose metabolic process lipid metabolic process fatty acid metabolic process triglyceride metabolic process transport carnitine metabolic process positive regulation of fatty acid beta-oxidation eating behavior regulation of fatty acid oxidation regulation of insulin secretion protein homooligomerization fatty acid beta-oxidation carnitine shuttle circadian rhythm response to organic cyclic compound epithelial cell differentiation response to drug cellular response to fatty acid regulation of fatty acid beta-oxidation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CPT1A Monoclonal Antibody (5D8G9)

CPT1A Antibody (66039-1-IG) in IHC (P)

Product Details

66039-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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