Proteintech

CREB1 Polyclonal Antibody

CREB1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 23

CREB1 Antibody (12208-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CREB1 antibody (Product # 12208-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

CREB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CREB1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12208-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 81 publications 81 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

View 6 publications 6 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CREB1 Fusion Protein Ag2852 (1-341 aa encoded by BC010636)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTMESGAEN QQSGDAAVTE AENQQMTVQA QPQIATLAQV SMPAAHATSS APTVTLVQLP NGQTVQVHGV IQAAQPSVIQ SPQVQTVQSS CKDLKRLFSG TQISTIAESE DSQESVDSVT DSQKRREILS RRPSYRKILN DLSSDAPGVP RIEEEKSEEE TSAPAITTVT VPTPIYQTSS GQYIAITQGG AIQLANNGTD GVQGLQTLTM TNAAATQPGT TILQYAQTTD GQQILVPSNQ VVVQAASGDV QTYQIRTAPT STIAPGVVMA SSPALPTQPA EEAARKREVR LMKNREAARE CRRKKKEYVK CLENRVAVLE NQNKTLIEEL KALKDLYCHK SD (1-341 aa encoded by BC010636)

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Niu R,Chen H,Manthari RK,Sun Z,Wang J,Zhang J,Wang J

Thu Mar 01 00:00:00 UTC 2018

Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus.

Chemosphere

Niu R,Chen H,Manthari RK,Sun Z,Wang J,Zhang J,Wang J

Thu Mar 01 00:00:00 UTC 2018

Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.

International journal of molecular medicine

Lv X,Wang D,Ma Y,Long Z

Thu Mar 01 00:00:00 UTC 2018

Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.

International journal of molecular medicine

Lv X,Wang D,Ma Y,Long Z

Thu Mar 01 00:00:00 UTC 2018

Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.

International journal of molecular medicine

Lv X,Wang D,Ma Y,Long Z

Thu Mar 01 00:00:00 UTC 2018

Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.

International journal of molecular medicine

Lv X,Wang D,Ma Y,Long Z

Thu Mar 01 00:00:00 UTC 2018

Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.

Neurochemical research

Cao Q,Xiao ZM,Wang X,Weng C,Ding M,Zhu F,Lu ZN

Fri Jun 01 00:00:00 UTC 2018

Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.

Neurochemical research

Cao Q,Xiao ZM,Wang X,Weng C,Ding M,Zhu F,Lu ZN

Fri Jun 01 00:00:00 UTC 2018

Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS₂ nanoflowers.

Toxicology research

Bai D,Li Q,Wang J,Zhao J,Deng X,Yuan L,Wu P

Thu Nov 01 00:00:00 UTC 2018

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

Aging

Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

Thu Dec 06 00:00:00 UTC 2018

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

Aging

Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

Thu Dec 06 00:00:00 UTC 2018

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

Aging

Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

Thu Dec 06 00:00:00 UTC 2018

A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

Aging

Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

Thu Dec 06 00:00:00 UTC 2018

Calretinin Participates in Regulating Steroidogenesis by PLC-Ca²⁺-PKC Pathway in Leydig Cells.

Scientific reports

Xu W,Zhu Q,Liu S,Dai X,Zhang B,Gao C,Gao L,Liu J,Cui Y

Wed May 09 00:00:00 UTC 2018

Calretinin Participates in Regulating Steroidogenesis by PLC-Ca²⁺-PKC Pathway in Leydig Cells.

Scientific reports

Xu W,Zhu Q,Liu S,Dai X,Zhang B,Gao C,Gao L,Liu J,Cui Y

Wed May 09 00:00:00 UTC 2018

Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.

Frontiers in pharmacology

Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

Sun Apr 10 00:00:00 UTC 2022

Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.

Frontiers in pharmacology

Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

Sun Apr 10 00:00:00 UTC 2022

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ_1-42-Induced Rat Model of Alzheimer's Disease.

BioMed research international

Sheng C,Xu P,Zhou K,Deng D,Zhang C,Wang Z

Thu Jun 07 00:00:00 UTC 2018

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ_1-42-Induced Rat Model of Alzheimer's Disease.

BioMed research international

Sheng C,Xu P,Zhou K,Deng D,Zhang C,Wang Z

Thu Jun 07 00:00:00 UTC 2018

Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.

The Journal of pathology

Avila DV,Barker DF,Zhang J,McClain CJ,Barve S,Gobejishvili L

Thu Sep 01 00:00:00 UTC 2016

Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.

The Journal of pathology

Avila DV,Barker DF,Zhang J,McClain CJ,Barve S,Gobejishvili L

Thu Sep 01 00:00:00 UTC 2016

Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.

Pharmacognosy magazine

Zhang Z,Wu H,Huang H

Sun May 01 00:00:00 UTC 2016

Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice.

Pharmacognosy magazine

Zhang Z,Wu H,Huang H

Sun May 01 00:00:00 UTC 2016

LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.

Scientific reports

Bian Z,Jin L,Zhang J,Yin Y,Quan C,Hu Y,Feng Y,Liu H,Fei B,Mao Y,Zhou L,Qi X,Huang S,Hua D,Xing C,Huang Z

Tue Apr 05 00:00:00 UTC 2016

LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.

Scientific reports

Bian Z,Jin L,Zhang J,Yin Y,Quan C,Hu Y,Feng Y,Liu H,Fei B,Mao Y,Zhou L,Qi X,Huang S,Hua D,Xing C,Huang Z

Tue Apr 05 00:00:00 UTC 2016

BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Huang SH,Wang J,Sui WH,Chen B,Zhang XY,Yan J,Geng Z,Chen ZY

Wed May 22 00:00:00 UTC 2013

BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Huang SH,Wang J,Sui WH,Chen B,Zhang XY,Yan J,Geng Z,Chen ZY

Wed May 22 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: active transcription factor CREB; cAMP response element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein

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Gene Aliases: 2310001E10Rik; 3526402H21Rik; AV083133; CREB; CREB-1; CREB1

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UniProt ID: (Human) P16220, (Mouse) Q01147, (Rat) P15337

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Entrez Gene ID: (Human) 1385, (Mouse) 12912, (Rat) 81646

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription cofactor activity protein binding enzyme binding Hsp70 protein binding histone acetyltransferase binding cAMP response element binding identical protein binding arrestin family protein binding DNA binding double-stranded DNA binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding

Process(es)

Performance Guarantee

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CREB1 Polyclonal Antibody

CREB1 Antibody (12208-1-AP) in ICC/IF

Product Details

12208-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

ChIP assay (ChIP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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