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Proteintech
CREB3 Polyclonal Antibody
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Product Details
11275-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CREB3 Fusion Protein Ag1823 (1-395 aa encoded by BC009402)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MELELDAGD QDLLAFLLEE SGDLGTAPDE AVRAPLDWAL PLSEVPSDWE VDDLLCSLLS PPASLNILSS SNPCLVHHDH TYSLPRETVS MDLESESCRK EGTQMTPQHM EELAEQEIAR LVLTDEEKSL LEKEGLILPE TLPLTKTEEQ ILKRVRRKIR NKRSAQESRR KKKVYVGGLE SRVLKYTAQN MELQNKVQLL EEQNLSLLDQ LRKLQAMVIE ISNKTSSSST CILVLLVSFC LLLVPAIYSS DTRGSLPAEH GVLSRQLRAL PSEDPYQLEL PALQSEVPKD STHQWLDGSD CVLQAPGNTS CLLHYMPQAP SAEPPLEWPF PDLFSEPLCR GPILPLQANL TRKGGWLPTG SPSVILQDRY SG (1-395 aa encoded by BC009402)
Target Information
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basic leucine zipper protein; CREB-3; cyclic AMP response element (CRE)-binding protein/activating transcription factor 1; Cyclic AMP-responsive element-binding protein 3; leucin zipper proitein; Leucine zipper protein; Luman; small leucine zipper protein; Transcription factor LZIP-alpha
Gene Aliases: CREB3; LUMAN; LZIP; sLZIP
UniProt ID: (Human) O43889
Entrez Gene ID: (Human) 10488
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
cAMP response element binding
transcription from RNA polymerase II promoter
chemotaxis
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
viral process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of monocyte chemotaxis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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