Proteintech

CREB3L1/OASIS Polyclonal Antibody

CREB3L1/OASIS Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

CREB3L1/OASIS Antibody (11235-2-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed A549 cells using 11235-2-AP (CREB3L1,OASIS antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CREB3L1/OASIS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CREB3L1/OASIS Antibody in Western Blot (WB)

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Product Details

11235-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CREB3L1,OASIS Fusion Protein Ag1757 (170-519 aa encoded by BC015781)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PHQAPGEMT QLPVIKAEPL EVNQFLKVTP EDLVQMPPTP PSSHGSDSDG SQSPRSLPPS SPVRPMARSS TAISTSPLLT APHKLQGTSG PLLLTEEEKR TLIAEGYPIP TKLPLTKAEE KALKRVRRKI KNKISAQESR RKKKEYVECL EKKVETFTSE NNELWKKVET LENANRTLLQ QLQKLQTLVT NKISRPYKMA ATQTGTCLMV AALCFVLVLG SLVPCLPEFS SGSQTVKEDP LAADGVYTAS QMPSRSLLFY DDGAGLWEDG RSTLLPMEPP DGWEINPGGP AEQRPRDHLQ HDHLDSTHET TKYLSEAWPK DGGNGTSPDF SHSKEWFHDR DLGPNTTIKL S (170-519 aa encoded by BC015781)

Target Information

Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Integrating network pharmacology and experimental verification to explore the mechanism of puerarin against oliguria in acute alcoholism.

Frontiers in pharmacology

Wan MX,Huang XJ,Li X,Suan J,Xu L

Fri Oct 28 00:00:00 UTC 2022

Effects of endoplasmic reticulum stress-mediated CREB3L1 on apoptosis of glioma cells.

Molecular and clinical oncology

Yan Z,Hu Y,Zhang Y,Pu Q,Chu L,Liu J

Fri Apr 01 00:00:00 UTC 2022

Effects of endoplasmic reticulum stress-mediated CREB3L1 on apoptosis of glioma cells.

Molecular and clinical oncology

Yan Z,Hu Y,Zhang Y,Pu Q,Chu L,Liu J

Fri Apr 01 00:00:00 UTC 2022

Comparison of the MAID (AI) and CAV/IE regimens with the predictive value of cyclic AMP-responsive element-binding protein 3 like protein 1 (CREB3L1) in palliative chemotherapy for advanced soft-tissue sarcoma patients.

Journal of Cancer

Xiao W,Liang Y,Que Y,Li J,Peng R,Xu B,Wen X,Zhao J,Guan Y,Zhang X

Wed Sep 30 00:00:00 UTC 2020

Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring.

Frontiers in endocrinology

Liu X,Wang J,Gao L,Jiao Y,Liu C

Wed Nov 20 00:00:00 UTC 2019

Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring.

Frontiers in endocrinology

Liu X,Wang J,Gao L,Jiao Y,Liu C

Wed Nov 20 00:00:00 UTC 2019

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy.

BMC cancer

Denard B,Jiang S,Peng Y,Ye J

Mon Aug 13 00:00:00 UTC 2018

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy.

BMC cancer

Denard B,Jiang S,Peng Y,Ye J

Mon Aug 13 00:00:00 UTC 2018

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy.

BMC cancer

Denard B,Jiang S,Peng Y,Ye J

Mon Aug 13 00:00:00 UTC 2018

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy.

BMC cancer

Denard B,Jiang S,Peng Y,Ye J

Mon Aug 13 00:00:00 UTC 2018

Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.

Breast cancer research : BCR

Ward AK,Mellor P,Smith SE,Kendall S,Just NA,Vizeacoumar FS,Sarker S,Phillips Z,Alvi R,Saxena A,Vizeacoumar FJ,Carlsen SA,Anderson DH

Mon Jan 25 00:00:00 UTC 2016

Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.

Breast cancer research : BCR

Ward AK,Mellor P,Smith SE,Kendall S,Just NA,Vizeacoumar FS,Sarker S,Phillips Z,Alvi R,Saxena A,Vizeacoumar FJ,Carlsen SA,Anderson DH

Mon Jan 25 00:00:00 UTC 2016

Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.

Breast cancer research : BCR

Ward AK,Mellor P,Smith SE,Kendall S,Just NA,Vizeacoumar FS,Sarker S,Phillips Z,Alvi R,Saxena A,Vizeacoumar FJ,Carlsen SA,Anderson DH

Mon Jan 25 00:00:00 UTC 2016

Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.

Breast cancer research : BCR

Ward AK,Mellor P,Smith SE,Kendall S,Just NA,Vizeacoumar FS,Sarker S,Phillips Z,Alvi R,Saxena A,Vizeacoumar FJ,Carlsen SA,Anderson DH

Mon Jan 25 00:00:00 UTC 2016

OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.

Epigenetics

Rose M,Schubert C,Dierichs L,Gaisa NT,Heer M,Heidenreich A,Knüchel R,Dahl E

Mon Dec 01 00:00:00 UTC 2014

OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration.

PloS one

Vellanki RN,Zhang L,Volchuk A

Thu Jun 27 00:00:00 UTC 2013

OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration.

PloS one

Vellanki RN,Zhang L,Volchuk A

Thu Jun 27 00:00:00 UTC 2013

OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration.

PloS one

Vellanki RN,Zhang L,Volchuk A

Thu Jun 27 00:00:00 UTC 2013

OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.

Endocrinology

Vellanki RN,Zhang L,Guney MA,Rocheleau JV,Gannon M,Volchuk A

Wed Sep 01 00:00:00 UTC 2010

OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.

Endocrinology

Vellanki RN,Zhang L,Guney MA,Rocheleau JV,Gannon M,Volchuk A

Wed Sep 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: BBF-2 homolog; cAMP responsive element binding protein 3-like 1; cAMP-responsive element-binding protein 3-like protein 1; Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS; old astrocyte specifically induced substance; Old astrocyte specifically-induced substance

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Gene Aliases: CREB3L1; OASIS; PSEC0238

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UniProt ID: (Human) Q96BA8, (Mouse) Q9Z125, (Rat) Q66HA2

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Entrez Gene ID: (Human) 90993, (Mouse) 26427, (Rat) 362165

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Function(s)

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein binding cAMP response element binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding transcription factor activity, sequence-specific DNA binding

Process(es)

osteoblast differentiation transcription from RNA polymerase II promoter multicellular organism development endoplasmic reticulum unfolded protein response extracellular matrix constituent secretion negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress transcription, DNA-templated regulation of transcription, DNA-templated response to unfolded protein regulation of ossification positive regulation of transcription from RNA polymerase II promoter regulation of bone mineralization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CREB3L1/OASIS Polyclonal Antibody

CREB3L1/OASIS Antibody (11235-2-AP) in ICC/IF

Product Details

11235-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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