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Invitrogen
CREM Polyclonal Antibody
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Product Details
PA5-29927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CREM. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547401
Product Specific Information
Recommended positive controls: NT2D1, Neuro2A, GL261, PC-12, Rat2.
Predicted reactivity: Mouse (93%), Rat (91%), Dog (86%), Chicken (88%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP response element modulator; cAMP responsive element moderator; cAMP-responsive element modulator; CRE modulator; CREM 2alpha-b protein; CREM 2beta-a protein; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; inducible cyclic AMP early repressor; MGC111110; MGC17881; MGC41893; OTTHUMP00000019443
Gene Aliases: CREM; CREM-2; hCREM-2; ICER; ICERI
UniProt ID: (Human) Q03060, (Rat) Q03061, (Mouse) P27699
Entrez Gene ID: (Human) 1390, (Rat) 25620, (Mouse) 12916
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
fatty acid metabolic process
glycosphingolipid metabolic process
spermatogenesis
cAMP-mediated signaling
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
response to cAMP
rhythmic process
signal transduction
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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