Bioss

CRF Polyclonal Antibody

View all (10) CRF antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-0382R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human CRF, amino acids 145-185.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Corticoliberin; corticotropin releasing factor; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF

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Gene Aliases: CRF; CRH; CRH1; Gm1347

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UniProt ID: (Human) P06850, (Rat) P01143, (Mouse) Q8CIT0

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Entrez Gene ID: (Human) 1392, (Rat) 81648, (Mouse) 12918

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Function(s)
receptor binding hormone activity neuropeptide hormone activity protein binding corticotropin-releasing hormone activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding
Process(es)
positive regulation of protein phosphorylation synaptic transmission, dopaminergic glucocorticoid biosynthetic process inflammatory response signal transduction chemical synaptic transmission female pregnancy parturition learning or memory positive regulation of cell proliferation associative learning hormone-mediated apoptotic signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of circadian sleep/wake cycle, wakefulness positive regulation of cell death regulation of serotonin secretion diterpenoid metabolic process hypothalamus development lung development adrenal gland development positive regulation of cAMP biosynthetic process negative regulation of epinephrine secretion negative regulation of luteinizing hormone secretion locomotory exploration behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus response to immobilization stress negative regulation of circadian sleep/wake cycle, REM sleep response to drug response to estrogen response to ethanol response to ether negative regulation of blood pressure response to pain ion homeostasis response to corticosterone positive regulation of corticotropin secretion positive regulation of cortisol secretion long-term synaptic potentiation positive regulation of digestive system process negative regulation of cell death negative regulation of glucagon secretion cellular response to cocaine cellular response to dexamethasone stimulus positive regulation of calcium ion import regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of corticosterone secretion positive regulation of behavioral fear response steroid metabolic process response to cocaine
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