Invitrogen

CRF Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-113738

Applications
Tested Dilution
Publications

Western Blot (WB)

1.0 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the C-terminal region of Human CRH (aa 142-191).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2884253

Product Specific Information

Immunogen sequence: GGHQEAPERE RRSEEPPISL DLTFHLLREV LEMARAEQLA QQAHSNRKLM

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology: Cow: 85%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 92%; Zebrafish: 93%

Target Information

Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF

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Gene Aliases: CRF; CRH; CRH1

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UniProt ID: (Human) P06850

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Entrez Gene ID: (Human) 1392

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Function(s)
receptor binding hormone activity neuropeptide hormone activity protein binding corticotropin-releasing hormone activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding
Process(es)
positive regulation of protein phosphorylation synaptic transmission, dopaminergic glucocorticoid biosynthetic process inflammatory response signal transduction chemical synaptic transmission female pregnancy parturition learning or memory positive regulation of cell proliferation associative learning hormone-mediated apoptotic signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of circadian sleep/wake cycle, wakefulness positive regulation of cell death regulation of serotonin secretion diterpenoid metabolic process hypothalamus development lung development adrenal gland development positive regulation of cAMP biosynthetic process negative regulation of epinephrine secretion negative regulation of luteinizing hormone secretion locomotory exploration behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus response to immobilization stress negative regulation of circadian sleep/wake cycle, REM sleep response to drug response to estrogen response to ethanol response to ether negative regulation of blood pressure response to pain ion homeostasis response to corticosterone positive regulation of corticotropin secretion positive regulation of cortisol secretion long-term synaptic potentiation positive regulation of digestive system process negative regulation of cell death negative regulation of glucagon secretion cellular response to cocaine cellular response to dexamethasone stimulus positive regulation of calcium ion import regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of corticosterone secretion positive regulation of behavioral fear response
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