Alomone Labs, LTD

CRF2/CRHR2 (extracellular) Polyclonal Antibody

View all (15) CRHR2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ACR-052-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Flow Cytometry (Flow)

5 µg /5x10^5 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)EELLLDGWGEPPDPE, corresponding to amino acid residues 20-34 of rat CRHR2, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: corticotrophin releasing hormone receptor 2; corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2; Corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; Corticotropin-releasing hormone receptor 2; CRF 2 receptor; CRF-R 2; CRF-R-2; CRF-R2; CRF-RB; CRF2; CRF2 receptor, beta isoform; CRFR-2; CRH receptor 2 variant B; CRH-R 2; CRH-R-2; CRH-R2; Crh2 receptor

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Gene Aliases: CRF-R2; CRF-RB; CRF2; CRF2R; CRFR2; CRFR2alpha; CRFR2beta; CRH2R; CRHR2; HM-CRF

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UniProt ID: (Human) Q13324, (Rat) P47866, (Mouse) Q60748

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Entrez Gene ID: (Human) 1395, (Rat) 64680, (Mouse) 12922

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Function(s)
protein binding corticotrophin-releasing factor receptor activity peptide hormone binding corticotropin-releasing hormone receptor activity G-protein coupled receptor activity hormone activity signal transducer activity transmembrane signaling receptor activity
Process(es)
actin filament organization cell surface receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway hormone-mediated signaling pathway positive regulation of heart rate positive regulation of gene expression negative regulation of gene expression negative regulation of norepinephrine secretion positive regulation of serotonin secretion sensory perception of pain cerebellum development hypothalamus development negative regulation of cAMP biosynthetic process positive regulation of cAMP biosynthetic process epithelial cell differentiation positive regulation of interleukin-6 production negative regulation of epinephrine secretion positive regulation of stress-activated MAPK cascade negative regulation of luteinizing hormone secretion gastric motility catecholamine biosynthetic process positive regulation of blood pressure negative regulation of follicle-stimulating hormone secretion skeletal muscle tissue growth positive regulation of NF-kappaB transcription factor activity long-term synaptic potentiation negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of ERK1 and ERK2 cascade cellular response to corticotropin-releasing hormone stimulus cellular response to glucocorticoid stimulus negative regulation of calcium ion import negative regulation of feeding behavior negative regulation of defecation G-protein coupled receptor signaling pathway feeding behavior negative regulation of angiogenesis positive regulation of cAMP metabolic process positive regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling signal transduction
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