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Invitrogen
CRHBP Monoclonal Antibody (C11)
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CRHBP Antibody (MA5-41573) in IHC (P)
Immunohistochemistry analysis of CRHBP in paraffin-embedded Rat Cardiac Muscle tissue. Samples were incubated with monoclonal antibody (Product # MA5-41573) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG using a dilution of 2 µg/mL.
Product Details
MA5-41573
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C11
Immunogen
Recombinant protein Corticotropin Releasing Hormone Binding Protein. The antigen corresponds to amino acid range 25-322 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899055
Target Information
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus. CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. CRH is produced not only in the hypothalamus but also in peripheral tissues, such as T lymphocytes; it is highly expressed in human placenta. Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta. This stimulation is in contrast to the glucocorticoid suppression of CRH expression in hypothalamus. The gene which encodes CRH maps to human chromosome 8q13. Human plasma contains a CRH-binding protein, CRH-BP (also designated CRF-BP) which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. The gene which encodes CRF-BP maps to human chromosome 5q11.2-q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: corticotropin releasing factor binding protein; corticotropin-releasing factor-binding protein; corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; CRH-BP
Gene Aliases: Crfbp
Entrez Gene ID: (Rat) 29625
synaptic transmission, dopaminergic
maternal aggressive behavior
inflammatory response
female pregnancy
hormone-mediated signaling pathway
cellular response to drug
cellular response to potassium ion
hormone metabolic process
regulated exocytosis
behavioral response to ethanol
regulation of corticotropin secretion
negative regulation of corticotropin secretion
cellular response to calcium ion
cellular response to cocaine
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to estrogen stimulus
cellular response to estradiol stimulus
cellular response to gonadotropin-releasing hormone
negative regulation of corticotropin-releasing hormone receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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