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Invitrogen
CRHR1 Monoclonal Antibody (343919)
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Product Details
MA5-24079
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
343919
Immunogen
NS0 mouse myeloma cell line transfected with human CRHR-1 Ser24-Val415
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608931
Product Specific Information
This antibody detects human CRHR-1 transfectants but not irrelevant transfectants.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; Crf receptor 1; Crf type 1; CRF-R-1; Crf1 receptor; CRH receptor 1; CRH-R-1; CRH-R1h; CRHR1f; seven transmembrane helix receptor
Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1; CRHR1L
UniProt ID: (Human) P34998
Entrez Gene ID: (Human) 1394
immune response
cell surface receptor signaling pathway
activation of adenylate cyclase activity
female pregnancy
parturition
regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
corticotropin secretion
cellular response to corticotropin-releasing hormone stimulus
negative regulation of voltage-gated calcium channel activity
regulation of corticosterone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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