Invitrogen

CRHR1 Recombinant Rabbit Monoclonal Antibody (4H5L2)

View all (12) CRHR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

702611

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

1:500
-

Immunocytochemistry (ICC/IF)

1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

4H5L2

Immunogen

Peptide corresponding to human CRHR1 [aa425-aa444]
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2734802

Product Specific Information

This antibody is predicted to react with Monkey, Dog, Pig, Rabbit.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; Corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; Crf receptor 1; Crf type 1; CRF-R; CRF-R-1; CRF-R1; CRF1; Crf1 receptor; CRFR-1; CRH receptor 1; CRH-R 1; CRH-R-1; CRH-R1; CRH-R1h; CRHR1f; seven transmembrane helix receptor

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Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1; CRHR1L

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UniProt ID: (Human) P34998, (Rat) P35353

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Entrez Gene ID: (Human) 1394, (Rat) 58959

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Function(s)
protein binding corticotrophin-releasing factor receptor activity G-protein alpha-subunit binding G-protein coupled receptor activity protein complex binding peptide binding corticotropin-releasing hormone receptor activity corticotropin-releasing hormone binding
Process(es)
response to hypoxia G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway memory feeding behavior visual learning hormone-mediated signaling pathway regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway hypothalamus development adrenal gland development positive regulation of cAMP biosynthetic process epithelial cell differentiation negative regulation of epinephrine secretion locomotory exploration behavior response to immobilization stress fear response positive regulation of mast cell degranulation behavioral response to cocaine behavioral response to ethanol regulation of synaptic plasticity behavioral response to pain corticotropin secretion response to electrical stimulus general adaptation syndrome, behavioral process long-term synaptic potentiation cellular response to corticotropin-releasing hormone stimulus negative regulation of neuron death negative regulation of voltage-gated calcium channel activity negative regulation of feeding behavior regulation of corticosterone secretion immune response cell surface receptor signaling pathway activation of adenylate cyclase activity female pregnancy parturition
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