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Invitrogen
CRIM2 Polyclonal Antibody
Product Details
PA5-34411
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551763
Product Specific Information
A suggested positive control is Jurkat cell lysate.
PA5-34411 can be used with blocking peptide PEP-1453.
Target Information
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRIM-2; cysteine rich BMP regulator 2 (chordin like); cysteine rich BMP regulator 2 (chordin-like); Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; kielin; Kielin/chordin-like protein; Kielin/chordin-like protein 1
Gene Aliases: AW060220; CRIM-2; CRIM2; Gm793; KCP; KCP-1; KCP1; NET67; RGD1561119
UniProt ID: (Human) Q6ZWJ8, (Mouse) Q3U492
Entrez Gene ID: (Human) 375616, (Rat) 296952, (Mouse) 333088
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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