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Bioss
CRIPTO Monoclonal Antibody (2B11)
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Product Details
BSM-2141M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
2B11
Immunogen
KLH conjugated synthetic peptide derived from human Teratocarcinoma-derived growth factor 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRGF; Cripto, EGF-CFC family member; Cripto-1; Cripto-1 growth factor; Cripto-3; Epidermal growth factor-like cripto protein CR1; Protein Cripto; TDGF2; Teratocarcinoma-derived growth factor 1
Gene Aliases: CR; CRGF; CRIPTO; CRIPTO-1; TDGF1
UniProt ID: (Human) P13385
Entrez Gene ID: (Human) 6997, (Rat) 680246
activation of MAPK activity
vasculogenesis
in utero embryonic development
morphogenesis of a branching structure
positive regulation of cell-matrix adhesion
cell migration involved in sprouting angiogenesis
epidermal growth factor receptor signaling pathway
gastrulation
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
anterior/posterior axis specification
regulation of signal transduction
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to hepatocyte growth factor stimulus
nodal signaling pathway
negative regulation of apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
embryo development
cell differentiation
mammary gland development
somatic stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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