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Product Details
PA5-114295
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human CRK
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884809
Product Specific Information
Immunogen sequence: PVPYVEKYRP ASASVSALIG GNQEGSHPQP LGGPEPGPYA QPSVNTPLPN
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Information
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter molecule crk; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; Proto-oncogene c-Crk; SAPK2a; Stress-activated protein kinase 2a; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein
Gene Aliases: CRK; CRKII; CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
UniProt ID: (Human) P46108, (Human) Q16539
Entrez Gene ID: (Human) 1398, (Human) 1432
SH3/SH2 adaptor activity
protein binding
SH2 domain binding
protein phosphorylated amino acid binding
ephrin receptor binding
protein serine/threonine kinase activity
MAP kinase activity
MAP kinase kinase activity
ATP binding
protein C-terminus binding
enzyme binding
protein phosphatase binding
NFAT protein binding
activation of MAPKK activity
regulation of transcription from RNA polymerase II promoter
regulation of actin cytoskeleton organization
regulation of Rac protein signal transduction
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
DNA damage checkpoint
activation of MAPK activity
cell morphogenesis
cartilage condensation
angiogenesis
placenta development
chondrocyte differentiation
glucose metabolic process
transcription, DNA-templated
apoptotic process
movement of cell or subcellular component
chemotaxis
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
Ras protein signal transduction
skeletal muscle tissue development
response to glucose
positive regulation of gene expression
positive regulation of myotube differentiation
myoblast differentiation involved in skeletal muscle regeneration
peptidyl-serine phosphorylation
fatty acid oxidation
osteoclast differentiation
positive regulation of cyclase activity
lipopolysaccharide-mediated signaling pathway
response to muramyl dipeptide
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
response to muscle stretch
p38MAPK cascade
positive regulation of protein import into nucleus
signal transduction in response to DNA damage
positive regulation of blood vessel endothelial cell migration
positive regulation of erythrocyte differentiation
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
protein autophosphorylation
regulation of sequence-specific DNA binding transcription factor activity
striated muscle cell differentiation
positive regulation of muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
3'-UTR-mediated mRNA stabilization
cellular response to lipopolysaccharide
cellular response to ionizing radiation
negative regulation of canonical Wnt signaling pathway
positive regulation of brown fat cell differentiation
stress-induced premature senescence
cellular response to virus
regulation of cytokine production involved in inflammatory response
positive regulation of myoblast fusion
regulation of signal transduction by p53 class mediator
positive regulation of reactive oxygen species metabolic process
positive regulation of interleukin-12 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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