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Proteintech
CRKRS Polyclonal Antibody
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Product Details
26816-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRKRS Fusion Protein Ag25323 (1300-1481 aa encoded by BC150265)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EAEPPGHLP HEHQALRPME YSTRPRPNRT YGNTDGPETG FSAIDTDERN SGPALTESLV QTLVKNRTFS GSLSHLGESS SYQGTGSVQF PGDQDLRFAR VPLALHPVVG QPFLKAEGSS NSVVHAETKL QNYGELGPGT TGASSSGAGL HWGGPTQSSA YGKLYRGPTR VPPRGGRGRG VPY (1300-1481 aa encoded by BC150265)
Target Information
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CrkRS; Cyclin-dependent kinase 12; H KIAA0904; hCDK12
Gene Aliases: CDK12; CRK7; CRKR; CRKRS; KIAA0904
UniProt ID: (Human) Q9NYV4
Entrez Gene ID: (Human) 51755
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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