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Immunogen sequence: HTAVISPQDP TLLIGSSLLA TCSVHGDPPG ATAEGLYWTL NGRRLPPELS RVLNASTLAL ALANLNGSRQ RSGDNLVCHA RDGSILAGSC LYVGLP
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
CRLF1 encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: class I cytokine receptor; CLF-1; Cytokine receptor-like factor 1; cytokine type 1 receptor CRLP-1; Cytokine-like factor 1; ZcytoR5
Gene Aliases: CISS; CISS1; CLF; CLF-1; CRLF1; NR6; UNQ288/PRO327; zcytor5
UniProt ID: (Human) O75462
Entrez Gene ID: (Human) 9244
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