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Product Details
PA5-28954
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human beta A3 Crystallin Recombinant protein.
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2546430
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji, mouse fetal eye.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (84%), Dog (96%), Rabbit (96%), Chicken (84%), Rhesus Monkey (97%), Bovine (93%), Guinea pig (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta crystallin A3 chain transcript CN; beta crystallin A3 chain transcript LAM; beta crystallin A3 chain transcript PS; beta crystallin A3 chain transcript TC; beta-A1-crystallin; beta-A3/A1-crystallin; beta-crystallin A1; Beta-crystallin A3; crystallin beta A3; crystallin beta A3/A1; crystallin, beta A1; crystallin, beta A3; eye lens structural protein; truncated beta-crystallin A3
Gene Aliases: BA3/A1; Cryb; CRYB1; CRYBA1; CTRCT10
UniProt ID: (Human) P05813
Entrez Gene ID: (Human) 1411, (Mouse) 12957
visual perception
camera-type eye development
negative regulation of cytokine production
lens development in camera-type eye
negative regulation of phosphatidylinositol 3-kinase signaling
negative regulation of TOR signaling
negative regulation of protein kinase B signaling
negative regulation of ERK1 and ERK2 cascade
positive regulation of anoikis
Performance Guarantee
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