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Product Details
18154-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRYBB2 Fusion Protein Ag12906 (1-205 aa encoded by BC069535)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASDHQTQA GKPQSLNPKI IIFEQENFQG HSHELNGPCP NLKETGVEKA GSVLVQAGPW VGYEQANCKG EQFVFEKGEY PRWDSWTSSR RTDSLSSLRP IKVDSQEHKI ILYENPNFTG KKMEIIDDDV PSFHAHGYQE KVSSVRVQSG TWVGYQYPGY RGLQYLLEKG DYKDSSDFGA PHPQVQSVRR IRDMQWHQRG AFHPSN (1-205 aa encoded by B C069535)
Target Information
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta crystallin B2; Beta crystallin Bp; Beta-B2 crystallin; Beta-crystallin B2; Beta-crystallin Bp; CCA 2; CRYB B2; CRYBB 2; crystallin, beta B2; CTA-221G9.7; eye lens structural protein; OTTHUMP00000198622; R.norvegicus CRYBB2 gene (crystallin, beta B2)
Gene Aliases: CCA2; Cryb-2; CRYB2; CRYB2A; CRYBB2; CTRCT3; D22S665
UniProt ID: (Human) P43320, (Mouse) P62696, (Rat) P62697
Entrez Gene ID: (Human) 1415, (Mouse) 12961, (Rat) 25422
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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