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Proteintech
CRYGC Polyclonal Antibody
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Product Details
17931-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRYGC Fusion Protein Ag12362 (1-174 aa encoded by BC074955)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGKITFYED RAFQGRSYET TTDCPNLQPY FSRCNSIRVE SGCWMLYERP NYQGQQYLLR RGEYPDYQQW MGLSDSIRSC CLIPQTVSHR LRLYEREDHK GLMMELSEDC PSIQDRFHLS EIRSLHVLEG CWVLYELPNY RGRQYLLRPQ EYRRCQDWGA MDAKAGSLRR VVDLY (1-174 aa encoded by BC074955)
Target Information
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: crystallin, gamma C; crystallin, gamma polypeptide 3; Gamma-C-crystallin; Gamma-crystallin 2-1; Gamma-crystallin 3; Gamma-crystallin C; gammaC-crystallin
Gene Aliases: CCL; Cryg; Cryg-5; CRYG3; CRYGC; CTRCT2; Gammab-cry; Len
UniProt ID: (Human) P07315, (Rat) P02529, (Mouse) Q61597
Entrez Gene ID: (Human) 1420, (Rat) 24277, (Mouse) 12966
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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