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Immunogen sequence: HGGRVIVVGS RGTIEINPRD TMAKESSIIG VTLFSSTKEE FQQYAAALQA GMEIGWLKPV IGSQYPLEKV AEAHENIIHG SGA
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: crystallin, zeta (quinone reductase); nadph quinone reductase; NADPH:quinone reductase; Quinone oxidoreductase; zeta crystallin; Zeta-crystallin
Gene Aliases: CRYZ
UniProt ID: (Human) Q08257
Entrez Gene ID: (Human) 1429
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