Proteintech

CSE1L Polyclonal Antibody

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Questions & Answers

Questions & Answers

Antibody Testing Data (18)

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 18

CSE1L Antibody (22219-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 22219-1-AP) (CSE1L antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Western Blot (WB)

CSE1L Antibody in Immunoprecipitation (IP)

Product Image Gallery

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 22219-1-AP) (CSE1L antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 40x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 10x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human placenta tissue slide using (Product # 22219-1-AP) CSE1L antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human placenta tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 40x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human placenta tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 10x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human testis tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 40x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human testis tissue slide using 22219-1-AP (CSE1L Antibody) at dilution of 1:50 (under 10x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 22219-1-AP (CSE1L antibody) at dilution of 1:50 (under 40x lens).

CSE1L Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 22219-1-AP (CSE1L antibody) at dilution of 1:50 (under 10x lens).

CSE1L Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 22219-1-AP) CSE1L antibody at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — Mouse testis tissue were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — RAW264.7 cells were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — MCF7 cells were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 22219-1-AP (CSE1L antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

CSE1L Antibody in Immunoprecipitation (IP) — IP result of anti-CSE1L (IP:22219-1-AP, 4ug; Detection:22219-1-AP 1:1000) with HEK-293 cells lysate 2700ug.

Product Details

22219-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

-

Miscellaneous PubMed (MISC)

-

View 1 publication 1 publication

Not applicable (N/A)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CSE1L Fusion Protein Ag17556 (627-971 aa encoded by BC109313)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RITCKANPA AVVNFEEALF LVFTEILQND VQEFIPYVFQ VMSLLLETHK NDIPSSYMAL FPHLLQPVLW ERTGNIPALV RLLQAFLERG SNTIASAAAD KIPGLLGVFQ KLIASKANDH QGFYLLNSII EHMPPESVDQ YRKQIFILLF QRLQNSKTTK FIKSFLVFIN LYCIKYGALA LQEIFDGIQP KMFGMVLEKI IIPEIQKVSG NVEKKICAVG ITKLLTECPP MMDTEYTKLW TPLLQSLIGL FELPEDDTIP DEEHFIDIED TPGYQTAFSQ LAFAGKKEHD PVGQMVNNPK IHLAQSLHKL STACPGRVPS MVSTSLNAEA LQYLQGYLQA ASVTLL (627-971 aa encoded by BC109313)

Target Information

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Cancers

Bellio C,Emperador M,Castellano P,Gris-Oliver A,Canals F,Sánchez-Pla A,Zamora E,Arribas J,Saura C,Serra V,Tabernero J,Littlefield BA,Villanueva J

Mon May 23 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer.

International journal of oncology

Chang CC,Kao WY,Liu CY,Su HH,Kan YA,Lin PY,Ku WC,Chang KW,Yang RN,Huang CJ

Wed Jun 01 00:00:00 UTC 2022

CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway.

Journal of Cancer

Zhang X,Zhang X,Mao T,Xu H,Cui J,Lin H,Wang L

Fri Apr 16 00:00:00 UTC 2021

Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.

Cell reports

Hiatt J,Cavero DA,McGregor MJ,Zheng W,Budzik JM,Roth TL,Haas KM,Wu D,Rathore U,Meyer-Franke A,Bouzidi MS,Shifrut E,Lee Y,Kumar VE,Dang EV,Gordon DE,Wojcechowskyj JA,Hultquist JF,Fontaine KA,Pillai SK,Cox JS,Ernst JD,Krogan NJ,Marson A

Tue May 11 00:00:00 UTC 2021

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

Nature immunology

Hubel P,Urban C,Bergant V,Schneider WM,Knauer B,Stukalov A,Scaturro P,Mann A,Brunotte L,Hoffmann HH,Schoggins JW,Schwemmle M,Mann M,Rice CM,Pichlmair A

Mon Apr 01 00:00:00 UTC 2019

RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.

The Journal of biological chemistry

Trotman JB,Agana BA,Giltmier AJ,Wysocki VH,Schoenberg DR

Fri Oct 26 00:00:00 UTC 2018

RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.

The Journal of biological chemistry

Trotman JB,Agana BA,Giltmier AJ,Wysocki VH,Schoenberg DR

Fri Oct 26 00:00:00 UTC 2018

Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II.

Molecular medicine reports

Cui J,Zhuang S,Qi S,Li L,Zhou J,Zhang W,Zhao Y,Qi N,Yin Y,Huang L

Wed Nov 01 00:00:00 UTC 2017

Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II.

Molecular medicine reports

Cui J,Zhuang S,Qi S,Li L,Zhou J,Zhang W,Zhao Y,Qi N,Yin Y,Huang L

Wed Nov 01 00:00:00 UTC 2017

CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.

Scientific reports

Cheng DD,Lin HC,Li SJ,Yao M,Yang QC,Fan CY

Fri Apr 07 00:00:00 UTC 2017

CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.

Scientific reports

Cheng DD,Lin HC,Li SJ,Yao M,Yang QC,Fan CY

Fri Apr 07 00:00:00 UTC 2017

CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.

Scientific reports

Cheng DD,Lin HC,Li SJ,Yao M,Yang QC,Fan CY

Fri Apr 07 00:00:00 UTC 2017

CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.

Scientific reports

Cheng DD,Lin HC,Li SJ,Yao M,Yang QC,Fan CY

Fri Apr 07 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1-like; Exp2; Exportin-2; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037

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Gene Aliases: 2610100P18Rik; AA407533; Capts; CAS; CSE1; CSE1L; XPO2

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UniProt ID: (Human) P55060, (Mouse) Q9ERK4

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Entrez Gene ID: (Human) 1434, (Mouse) 110750

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nuclear export signal receptor activity protein binding Ran GTPase binding

transport intracellular protein transport protein transport protein import into nucleus protein export from nucleus apoptotic process cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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