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Proteintech
CSK Monoclonal Antibody (3B12C5)
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Product Details
66115-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3B12C5
Immunogen
CSK Fusion Protein Ag12103 (83-450 aa encoded by BC106073)
Conjugate
Form
Liquid
Concentration
0.89 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FHGKITREQ AERLLYPPET GLFLVRESTN YPGDYTLCVS CDGKVEHYRI MYHASKLSID EEVYFENLMQ LVEHYTSDAD GLCTRLIKPK VMEGTVAAQD EFYRSGWALN MKELKLLQTI GKGEFGDVML GDYRGNKVAV KCIKNDATAQ AFLAEASVMT QLRHSNLVQL LGVIVEEKGG LYIVTEYMAK GSLVDYLRSR GRSVLGGDCL LKFSLDVCEA MEYLEGNNFV HRDLAARNVL VSEDNVAKVS DFGLTKEASS TQDTGKLPVK WTAPEALREK KFSTKSDVWS FGILLWEIYS FGRVPYPRIP LKDVVPRVEK GYKMDAPDGC PPAVYEVMKN CWHLDAAMRP SFLQLREQLE HIKTHELHL (83-450 aa encoded by BC106073)
Target Information
CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Src kinase; MGC117393; p50CSK; Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Aliases: AW212630; CSK; p50CSK
UniProt ID: (Human) P41240, (Mouse) P41241
Entrez Gene ID: (Human) 1445, (Mouse) 12988
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
protein C-terminus binding
kinase activity
protein phosphatase binding
protein kinase A catalytic subunit binding
identical protein binding
metal ion binding
proline-rich region binding
regulation of cytokine production
adaptive immune response
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
central nervous system development
brain development
negative regulation of cell proliferation
negative regulation of low-density lipoprotein particle clearance
cell migration
cell differentiation
T cell costimulation
negative regulation of interleukin-6 production
negative regulation of kinase activity
adherens junction organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of Golgi to plasma membrane protein transport
positive regulation of MAP kinase activity
innate immune response
negative regulation of bone resorption
oligodendrocyte differentiation
negative regulation of phagocytosis
T cell receptor signaling pathway
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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