Proteintech

CSNK2A1 Polyclonal Antibody

CSNK2A1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 20

CSNK2A1 Antibody (10992-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 10992-1-AP) (CSNK2A1 antibody), at dilution of 1:100 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Phalloidin stains the F-actin.

CSNK2A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSNK2A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10992-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CSNK2A1 Fusion Protein Ag1452 (1-391 aa encoded by BC011668)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGPVPSRA RVYTDVNTHR PREYWDYESH VVEWGNQDDY QLVRKLGRGK YSEVFEAINI TNNEKVVVKI LKPVKKKKIK REIKILENLR GGPNIITLAD IVKDPVSRTP ALVFEHVNNT DFKQLYQTLT DYDIRFYMYE ILKALDYCHS MGIMHRDVKP HNVMIDHEHR KLRLIDWGLA EFYHPGQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRK EPFFHGHDNY DQLVRIAKVL GTEDLYDYID KYNIELDPRF NDILGRHSRK RWERFVHSEN QHLVSPEALD FLDKLLRYDH QSRLTAREAM EHPYFYTVVK DQARMGSSSM PGGSTPVSSA NMMSGISSVP TPSPLGPLAG SPVIAAANPL GMPVPAAAGA QQ (1-391 aa encoded by BC011668)

Target Information

CSNK2A1 is a serine/threonine protein kinase that phosphorylates acidic proteins. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by CK2 alpha-1 represents the alpha subunit. While CK2 alpha-1 is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for CK2 alpha-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling.

Nucleic acids research

Matsumoto M,Modliszewski JL,Shinozaki K,Maezawa R,Perez VM,Ishikawa Y,Suzuki R,McKnight KL,Masaki T,Hirai-Yuki A,Kohara M,Lemon SM,Selitsky SR,Yamane D

Mon May 22 00:00:00 UTC 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 UTC 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 UTC 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 UTC 2023

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 UTC 2023

CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity.

International immunopharmacology

Luo Y,Lei Y,Guo X,Zhu D,Zhang H,Guo Z,Xu Z,Zhao H,Xi Y,Peng X,Xiao L,Wang Z,Niu X,Chen G

Thu Jun 01 00:00:00 UTC 2023

CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity.

International immunopharmacology

Luo Y,Lei Y,Guo X,Zhu D,Zhang H,Guo Z,Xu Z,Zhao H,Xi Y,Peng X,Xiao L,Wang Z,Niu X,Chen G

Thu Jun 01 00:00:00 UTC 2023

CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.

Journal of endocrinological investigation

Shu C,Wang S,Hu J,Xu M,Deng H,Maimaiti Y,Huang T

Wed Mar 01 00:00:00 UTC 2023

CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.

Journal of endocrinological investigation

Shu C,Wang S,Hu J,Xu M,Deng H,Maimaiti Y,Huang T

Wed Mar 01 00:00:00 UTC 2023

NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN.

Journal of translational medicine

Zhang R,Ai J,Wang J,Sun C,Lu H,He A,Li M,Liao Y,Lei J,Zhou F,Wu L,Liao W

Thu Jul 21 00:00:00 UTC 2022

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.

Nature communications

Guo Y,Zhu Z,Huang Z,Cui L,Yu W,Hong W,Zhou Z,Du P,Liu CY

Thu Aug 25 00:00:00 UTC 2022

ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters.

Nucleic acids research

Park K,Zhong J,Jang JS,Kim J,Kim HJ,Lee JH,Kim J

Fri Apr 22 00:00:00 UTC 2022

Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury.

Redox biology

Kong M,Dong W,Zhu Y,Fan Z,Miao X,Guo Y,Li C,Duan Y,Lu Y,Li Z,Xu Y

Fri Oct 01 00:00:00 UTC 2021

Structural insights into multifunctionality of human FACT complex subunit hSSRP1.

The Journal of biological chemistry

Li X,Li H,Jing Q,Wang M,Hu T,Li L,Zhang Q,Liu M,Fu YV,Han J,Su D

Wed Dec 01 00:00:00 UTC 2021

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.

Frontiers in molecular neuroscience

Dai L,Wang J,He M,Xiong M,Tian Y,Liu C,Zhang Z

Fri Aug 13 00:00:00 UTC 2021

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.

Frontiers in molecular neuroscience

Dai L,Wang J,He M,Xiong M,Tian Y,Liu C,Zhang Z

Fri Aug 13 00:00:00 UTC 2021

CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.

FEBS open bio

Shi Z,Wu D,Xu H,Yang J,Sun X

Sun Aug 01 00:00:00 UTC 2021

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Oncogene

Lu Y,Li X,Liu H,Xue J,Zeng Z,Dong X,Zhang T,Wu G,Yang K,Xu S

Mon Feb 01 00:00:00 UTC 2021

β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.

Biochemical and biophysical research communications

Zhang Y,Zhu Z,Ding H,Wan S,Zhang X,Li Y,Ji J,Wang X,Zhang M,Ye SD

Thu Apr 02 00:00:00 UTC 2020

Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling Pathway.

Journal of burn care & research : official publication of the American Burn Association

Niu X,Lin X,Chen X,Xu S,Huang Z,Tang Q

Mon Nov 30 00:00:00 UTC 2020

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication.

Nucleic acids research

Feng H,Lu J,Song X,Thongkum A,Zhang F,Lou L,Reizes O,Almasan A,Gong Z

Wed Nov 04 00:00:00 UTC 2020

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Journal of agricultural and food chemistry

Wang W,Wang M,Ruan Y,Tan J,Wang H,Yang T,Li J,Zhou Q

Wed Sep 11 00:00:00 UTC 2019

Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Jiang L,Zhang J,Hu N,Liu A,Zhu H,Li L,Tian Y,Chen X,Quan L

Sat Dec 01 00:00:00 UTC 2018

Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Jiang L,Zhang J,Hu N,Liu A,Zhu H,Li L,Tian Y,Chen X,Quan L

Sat Dec 01 00:00:00 UTC 2018

The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.

Bioscience, biotechnology, and biochemistry

Yu G,Liao J,Wu J,Ding J,Zhang L

Mon Oct 01 00:00:00 UTC 2018

Increased expression of protein kinase CK2α correlates with poor patient prognosis in epithelial ovarian cancer.

PloS one

Ma Z,Wang X,He J,Xia J,Li Y

Tue Aug 29 00:00:00 UTC 2017

Increased expression of protein kinase CK2α correlates with poor patient prognosis in epithelial ovarian cancer.

PloS one

Ma Z,Wang X,He J,Xia J,Li Y

Tue Aug 29 00:00:00 UTC 2017

Increased expression of protein kinase CK2α correlates with poor patient prognosis in epithelial ovarian cancer.

PloS one

Ma Z,Wang X,He J,Xia J,Li Y

Tue Aug 29 00:00:00 UTC 2017

Increased expression of protein kinase CK2α correlates with poor patient prognosis in epithelial ovarian cancer.

PloS one

Ma Z,Wang X,He J,Xia J,Li Y

Tue Aug 29 00:00:00 UTC 2017

Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.

Oncotarget

Zhang HX,Jiang SS,Zhang XF,Zhou ZQ,Pan QZ,Chen CL,Zhao JJ,Tang Y,Xia JC,Weng DS

Tue Oct 27 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: casein kinase 2 alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; casein kinase II, alpha 1 related sequence 4; CK II alpha; CK II alpha 3; CK2 catalytic subunit alpha; protein kinase CK2

View more View less

Gene Aliases: CK2A1; CKII; Ckiia; CSNK2A1; Csnk2a1-rs4; CSNK2A3

View more View less

UniProt ID: (Human) P68400, (Mouse) Q60737, (Rat) P19139

View more View less

Entrez Gene ID: (Human) 1457, (Mouse) 12995, (Rat) 116549

View more View less

Function(s)

protein serine/threonine kinase activity protein binding ATP binding beta-catenin binding protein phosphatase regulator activity protein N-terminus binding Hsp90 protein binding kinase activity

Process(es)

protein phosphorylation positive regulation of cell proliferation positive regulation of Wnt signaling pathway positive regulation of cell growth negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein catabolic process protein autophosphorylation regulation of catalytic activity mitotic spindle checkpoint regulation of cell growth transcription, DNA-templated regulation of transcription, DNA-templated Wnt signaling pathway regulation of cell proliferation rhythmic process protein folding apoptotic process signal transduction chaperone-mediated protein folding regulation of signal transduction by p53 class mediator

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

CSNK2A1 Polyclonal Antibody

CSNK2A1 Antibody (10992-1-AP) in ICC/IF

Product Details

10992-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!