OriGene

CTGF Monoclonal Antibody (OTI5H7), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF806803

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI5H7

Immunogen

Human recombinant protein fragment corresponding to amino acids 27-349 of human CTGF produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; H-CTGF; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839

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Gene Aliases: CCN2; CTGF; HCS24; IGFBP8; NOV2

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UniProt ID: (Human) P29279

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Entrez Gene ID: (Human) 1490

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Function(s)
fibronectin binding integrin binding protein binding insulin-like growth factor binding protein C-terminus binding growth factor activity heparin binding
Process(es)
cartilage condensation ossification angiogenesis regulation of cell growth tissue homeostasis transcription initiation from RNA polymerase II promoter cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway epidermis development response to wounding response to glucose organ senescence positive regulation of gene expression negative regulation of gene expression cell migration cell differentiation lung development regulation of chondrocyte differentiation response to estradiol positive regulation of collagen biosynthetic process response to anoxia intracellular signal transduction chondrocyte proliferation response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone positive regulation of cell differentiation positive regulation of JNK cascade positive regulation of cell activation response to mineralocorticoid positive regulation of stress fiber assembly cytosolic calcium ion transport positive regulation of cardiac muscle contraction negative regulation of cell death extracellular matrix constituent secretion positive regulation of G0 to G1 transition positive regulation of ERK1 and ERK2 cascade response to fatty acid DNA biosynthetic process reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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