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Invitrogen
CTHRC1 Monoclonal Antibody (5H1)
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Product Details
MA5-34885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5H1
Immunogen
Recombinant protein within Human CTHRC1 aa 1-243
Conjugate
Form
Liquid
Concentration
2.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848792
Product Specific Information
Positive Control: CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.
Target Information
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagen triple helix repeat-containing protein 1
Gene Aliases: CTHRC1; UNQ762/PRO1550
UniProt ID: (Human) Q96CG8
Entrez Gene ID: (Human) 115908
cell migration
positive regulation of protein binding
positive regulation of osteoblast proliferation
ossification involved in bone remodeling
positive regulation of osteoblast differentiation
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor stereocilium organization
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
establishment of planar polarity involved in neural tube closure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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